Interaction between Substrate and Oxygen Ligand Responsible for Effective O–O Bond Cleavage in Bovine Cytochrome P450 Steroid 21-Hydroxylase Proved by Raman Spectroscopy

Takehiko Tosha, Norio Kagawa, Miharu Arase, Michael R. Waterman and Teizo Kitagawa

The Journal of Biological Chemistry 283 ( 7 ): 3708 - 3717 , 2008