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Articles by L. Chen
Total Records ( 10 ) for L. Chen
  S. PENG , L. CHEN , J.G. QIN , J. HOU , N. YU , Z. LONG , E. LI and J. YE
  A 9-week feeding experiment was conducted to evaluate the effects of dietary vitamin E supplementation on growth, lipid peroxidation and fatty acid composition of black sea bream fed oxidized oil. The FL and OL diets contained fresh fish oil and oxidized oil, respectively, without additional vitamin E supplementation. Another four α-tocopherol levels (150, 250, 450 and 800 mg kg−1 diet) were used within the OL diet, giving a total of six experimental diets. Fish were hand-fed to apparent satiation twice daily. At end of the trial, the weight gain and survival rate of fish were significantly reduced by diets with oxidized oil, whereas hepatosomatic index was remarkably high in fish fed oxidized oil diet. However, vitamin E supplementation to diet significantly improved growth performance and increased vitamin E content in the liver. Although, liver thiobarbituric acid reactive substances and docosahexaenoic acid were significantly increased by dietary oxidized oil, their levels were reduced by dietary vitamin E supplementation. Our results indicate that the fish were performing the best at intermediate concentrations of α-tocopherol and a dose of >150 mg α-tocopherol kg−1 diet could reduce lipid peroxidation and improve fish growth performance when oxidized oils exist in diet.
  X. SHI , P. ZHUANG , L. ZHANG , L. CHEN , B. XU , G. FENG and X. HUANG
  This study tested the hypothesis that different starvation time for fish before blood sampling can influence the result of plasma biochemical analysis. Glucose (GLU), total cholesterol (CHOL), triglyceride (TGL) and total protein (TP) in the plasma of juvenile Amur sturgeon (Acipenser schrenckii) were measured after different starvation duration (0, 0.5, 1, 2 and 3 days). Starvation time had a significant influence on plasma GLU, CHOL, TGL and TP concentrations (P < 0.05). Plasma GLU and TP concentrations were unpredictably variable with duration of starvation. Plasma TGL and CHOL concentrations after 3 days starvation were significantly higher than that in fish starved for 0, 0.5, or 1 day, and no significant difference was found among fish starved for 0, 0.5, or 1 day. In order to get baseline value for these blood parameters, juvenile Amur sturgeon should be starved for 1 day.
  S Yao , S Wang , Y Zhu , L Luo , G Zhu , S Flies , H Xu , W Ruff , M Broadwater , I. H Choi , K Tamada and L. Chen

Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1–deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1–deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.

  L. Chen , D. J. Magliano , B. Balkau , R. Wolfe , L. Brown , A. M. Tonkin , P. Z. Zimmet and J. E. Shaw
  Aims  To evaluate how to most efficiently screen populations to detect people at high risk of incident Type 2 diabetes and those with prevalent, but undiagnosed, Type 2 diabetes.

Methods  Data from 5814 adults in the Australian Diabetes, Obesity and Lifestyle study were used to examine four different types of screening strategies. The strategies incorporated various combinations of cut-points of fasting plasma glucose, the non-invasive Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK1) and a modified version of the tool incorporating fasting plasma glucose (AUSDRISK2). Sensitivity, specificity, positive predictive value, screening costs per case of incident or prevalent undiagnosed diabetes identified and intervention costs per case of diabetes prevented or reverted were compared.

Results  Of the four strategies that maximized sensitivity and specificity, use of the non-invasive AUSDRISK1, followed by AUSDRISK2 in those found to be at increased risk on AUSDRISK1, had the highest sensitivity (80.3%; 95% confidence interval 76.6-84.1%), specificity (78.1%; 95% confidence interval 76.9-79.2%) and positive predictive value (22.3%; 95% confidence interval 20.2-24.4%) for identifying people with either prevalent undiagnosed diabetes or future incident diabetes. It required the fewest people (24.1%; 95% confidence interval 23.0-25.2%) to enter lifestyle modification programmes, and also had the lowest intervention costs and combined costs of running screening and intervention programmes per case of diabetes prevented or reverted.

Conclusions  Using a self-assessed diabetes risk score as an initial screening step, followed by a second risk score incorporating fasting plasma glucose, would maximize efficiency of identifying people with undiagnosed Type 2 diabetes and those at high risk of future diabetes.

  L. Chen , Q. Li , Z. Yang , Z. Ye , Y. Huang , M. He , J. Wen , X. Wang , B. Lu , J. Hu , C. Liu , C. Ling , S. Qu and R. Hu
  Aim  To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.

Methods  We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.

Results  Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (< 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (= 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (= 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (> 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (= 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both < 0.05).


  L. Chen , W.U. Kaigui and H.E. Pan
  Reliability is one of the major concerns for software engineers. Due to dynamic properties of the open environment, visited probability of each component might change after a certain amount of time. To maintain user’s requirement of the software system reliability, this study proposes a dynamic reliability maintenance mechanism based on monitoring and resources allocation. An open source monitoring software, named Glassbox, is adopted to observe the change of number of visits to each component. Besides, the path-based method is used to analyze the reliability of software system from components reliability in the run time. Sensitivity of each component is calculated using this model and the difficulty to improve each component’s reliability is analyzed. After that, considering the limited system resources, we propose a greedy algorithm for re-allocating resources reasonably according to component sensitivity and the difficulty to improve component reliability which can improve the system reliability. Finally, some simulation experiments are presented to evaluate our method. The results showed the effectiveness of the proposed mechanism in this study.
  W.G. Xia , A.Y. Abdullahi , J.J. Zuo , L. Chen and D.Y. Feng
  Nine hundred, 42 days old male yellow-feathered broilers were used to evaluate the effects of Creatine Monohydrate (CMH) on growth performance, carcass characteristics and meat quality. The birds received either a no-CMH diet (0 mg kg-1) a low (250 mg kg-1), a moderate (500 mg kg-1) or a high-CMH diet (1000 mg kg-1) for 21 days. CMH supplementation did not affect the average daily weight gain, average daily feed intake or feed efficiency. Additionally no significant differences were discovered in the dressing, eviscerated, breast muscle or thigh muscle percentage. However, there was a decreasing trend in the pH values of the pectoralis major at 24 h postmortem and of the thigh muscle at 45 min postmortem as the level of CMH supplementation increased. No significant difference was observed in cooking loss, shear force value, moisture or crude protein percentages. However, supplementing with CMH increased the slow-twitch red and the fast-twitch white fiber ratio in the gastrocnemius muscles. The results suggested that CMH supplementation has no effect on growth performance or carcass characteristics but it potentially triggered a transition from fast-twitch red muscle fibers to slow-twitch red and fast-twitch white muscle fibers.
  J.J. Zuo , W.G. Xia , J.H. Liu , A.Y. Abdullahi , L. Chen , M.H. Xia and D.Y. Feng
  The object of the study was to investigate the effects of Creatine Monohydrate (CMH) supplementation on glucose absorption, glucose oxidation and glycogen synthesis in skeletal muscle of broilers. Nine hundred, 42 days old broilers were randomly assigned to four treatments with five replicates per treatment and 45 birds per replicate. The birds received either a no-CMH diet (0 mg kg-1), a low (250 mg kg-1), a moderate (500 mg kg-1) or a high-CMH diet (1000 mg kg-1) for 21 days. The results showed that CMH supplementation did not affect serum glucose concentration but did increase lactate concentration (linear and quadratic, p<0.001) as CMH supplementation increased. The concentration of lactate in pectoralis major showed a quadratic effect (p = 0.036) in response to increasing CMH supplementation. For the thigh muscle, the concentration of lactate presented a decreasing effect (linear, p = 0.042). Pyruvic acid in the pectoralis major increased markedly (linear, p<0.004; quadratic, p<0.003) with increasing CMH comcentration but an opposite effect to that in the thigh muscle. The HK1 mRNA abundance in the pectoralis major was decreased by CMH supplementation (linear and quadratic, p<0.001) but the HK1 mRNA abundance in the thigh muscle was increased with a quadratic effect. CMH supplementation had increased Lactate Dehydrogenase (LDH) activity in pectoralis major (linear, p = 0.003; quadratic, p<0.001) while no significant effect on thigh muscle as CMH concentration increased. Thus, it was inferred that CMH supplementation may improve glucose oxidation with distribution difference in skeletal muscle. Additionally, CMH supplementation had no effect on the Glycogen Synthase (GYS), Glucose Transporter 1 (GLUT1) and Glucose Transporter 3 (GLUT3) mRNA abundance, macroglycogen or total glycogen concentration of the breast and thigh muscles. CMH supplementation significantly increased the AMPKα phosphorylation of the pectoralis major and demonstrated a quadratic effect (p = 0.002) as CMH supplementation increased. CMH supplement did not affect the AMPKα phosphorylation of the thigh muscle but presented the same effect as the pectoralis major. The results suggested that CMH supplementation did not affect glucose uptake and glycogen storage of skeletal muscle but it accelerate the glucose oxidation in the thigh muscle or decelerate glycolysis in the pectoralis major, possibly regulated by AMPKα phosphorylation.
  S. Chen , Q. Song , Y. Cheng and L. Chen
  Nowadays, the inventory misplacement is a significant issue in the supply chain management. This study analyzes how the managers consider using Radio Frequency Identification (RFID) to effectively eliminate misplacement problems and to improve profitability. A mean-risk framework is carried out to portray this issue and a central semi-deviation model is proposed for risk measurement to analyze the impact of risk attitude on RFID adoption. Both risk neutral and risk aversion cases are discussed in this study. By considering both fixed setup cost and the tag cost, it is proved that retailers do not always benefit more from implementing RFID, unless the level of available products and tag cost are both low enough. Under the risk analysis, it is found that a risk aversion manager will be more unwilling than a risk neutral manager to invest RFID technology. Moreover, the manager will be more unwilling to invest RFID if the manager is more risk-averse.
  J. Lu , Z. Dong , L. Chen and J. Yu
  We have theoretically and experimentally investigated polarization insensitive of all optical wavelength conversion for polarization multiplexing signal based on four-wave mixing (FWM) in nonlinear optical fiber. Optical polarization multiplexing technique can be used to double the transmission bit rate by adding data on each of two orthogonal optical states. At the receiver side, the two orthogonal signals can be obtained by direct detection. The eye diagrams of the original signals have been probed and compared with the converted one in this experiment. The characteristics of the converted signal have been fully studied and a little crosstalk which leads a better corresponding eye diagram has been obtained after polarization demultiplexing.
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