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Blood

Year: 2009  |  Volume: 113  |  Issue: 23  |  Page No.: 5811 - 5818

PD-1 on dendritic cells impedes innate immunity against bacterial infection

S Yao, S Wang, Y Zhu, L Luo, G Zhu, S Flies, H Xu, W Ruff, M Broadwater, I. H Choi, K Tamada and L. Chen

Abstract

Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1–deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1–deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.

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