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Articles by Ken Onda
Total Records ( 3 ) for Ken Onda
  Ken Onda , Chikako Noda , Kazue Nakamura , Reiichiro Sato , Hideharu Ochiai , Sachiko Arai , Hiroo Madarame , Kazuhiro Kawai and Fujiko Sunaga
  Background: This study investigated changes in the blood acid-base balance to determine the effects of Lactated Ringer’s Solution (LRS) administration in a steer with liver damage caused by carbon tetrachloride (CCl4) administration and in a cow with a fatty liver caused by a parturient negative energy balance. Materials and Methods: The LRS was administered to the CCl4 steer before CCl4 administration and 2, 7 and 11 days after CCl4 administration. The fatty liver cow and a group of control cows were administered LRS once. The initiation of LRS infusion was designated time-point 0. Venous blood samples were collected periodically from time-point 0-360 min thereafter and parameters related to the acid-base balance were measured. Results: On day 2, blood pH of the CCl4 steer before LRS administration was 7.26 but it gradually increased after the initiation of LRS administration, before ultimately recovering to within the normal reference range. The HCO3– levels decreased transiently just after the administration of LRS on day 7, then rapidly returned normal. Despite the fatty liver cow having severe fat infiltration, there were no substantial differences in parameters related to the blood acid-base balance between the fatty liver cow and the control cows, after LRS administration. Conclusion: Even in a steer suffering from liver damage caused by CCl4 administration, lactate was metabolised in the liver and worked as an alkaliser. Therefore, LRS may be a safe extracellular replacement solution when administered at the recommended flow rate and dose (20 mL kg–1 h–1 and 30 mL kg–1, respectively) to dairy cows in clinics.
  Ken Onda , Yukiko Emura , Aya Saito , Tooru Ikeyama , Reiichiro Sato , Hideharu Ochiai , Kazuyuki Kaneko , Tsunenori Iriki and Yasunori Wada
  Acute stress following surgical castration of calves is a common animal welfare concern. Administration of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) can reduce post-castration stress but treatments vary in cost and efficacy. In this study, the effectiveness of sodium salicylate in relieving stress during invasive castration of calves was assessed on the basis of changes in serum cortisol levels and was compared with the effectiveness of ketoprofen. Twenty male Holstein calves were divided into 4 groups: a sham-operated untreated group, a castrated untreated group and 2 castrated groups receiving NSAIDs (sodium salicylate or ketoprofen). NSAIDs were injected intravenously immediately before administering local anesthetic. Blood samples were collected at regular time intervals for measurement of cortisol concentrations. Serum cortisol concentrations of the calves that were administered sodium salicylate were lower than those of the calves that were not administered any NSAID at 1, 1.5 and 2 h after castration and higher than those of the calves that were administered ketoprofen at 2 h after castration (p<0.05). Although, the analgesic and anti-inflammatory effects of sodium salicylate are weaker than those of ketoprofen, the use of salicylic acid derivatives in surgical castration is useful from the viewpoint of animal welfare and entails a significantly lower cost.
  Ken Onda , Reiichiro Sato , Nobue Oba , Eriko Hashimoto , Hideharu Ochiai , Sachiko Arai , Kazuhiro Kawai , Kazuyuki Kaneko , Seigo Itoh and Yasunori Wada
  Leptin is secreted mainly from adipocytes, regulates energy metabolism and influences obesity and many other mechanisms. Milk contains higher concentrations of leptin than blood and mammary epithelial cells produce leptin. The present study examines leptin gene expression in the mammary glands of lactating and non-lactating cows using RT-PCR. The amplified PCR products were sequenced. Researchers found that unlike the mouse, the leptin mRNA is not expressed at all in the non-lactating mammary gland and is sometimes not expressed in the lactating mammary gland of cows. Sequencing analysis confirmed two leptin precursors like those of human and mouse. One precursor consisted of 167 amino acids and the other consisted of 166 amino acids with a deletion at glutamine 49. This study suggests that leptin may be associated with proliferation of mammary epithelial cells to prepare subsequent lactation during pregnancy.
 
 
 
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