Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by K.A.N. Esievo
Total Records ( 14 ) for K.A.N. Esievo
  M. Bisalla , K.A.N. Esievo , N.D.G. Ibrahim and I.A. Lawal
  Serum proteins, thyroid hormones and alkaline phosphatase concentrations were measured in Yankasa sheep experimentally infected with T. congolense. Parasitemia occurred in the T. congolense infected sheep immunomodulated with levamisole two days earlier than the infected group without immunodulation.Packed cell volume decreased significantly(p< 0.05) in the infected groups with and without immunomodulation when compared to the controls from the first week of infection up to the end of the experiment. Serum total protein, albumin, Thyroxine (T4) and Triiodothyronine (T3) decreased significantly (p< 0.05) in the infected sheep with and without immunodulation when compared to the controls. Serum Thyrotopin (TSH) and Alkaline Phosphate (AP) did not alter significantly (p>0.05) in the infected sheep with and without immunomodulation when compared to the controls throughout the period of the experiment. In general, levamisole administration did not appear to alter the infection when compared to the infected group without immunomodulation.
  S.J. Sambo , N.D.G. Ibrahim , K.A.N. Esievo , J.O. Hambolu , S.B. Oladele , A.K.B. Sackey and S.M. Makoshi
  A total of 518 cattle were examined and sampled at Zaria abattoir from November, 2001 to October, 2002. Skin specimens obtained after slaughter from the neck region were fixed in 10% buffered neutral formalin, processed, sectioned at 5 µm thickness and stained with Haematoxylin and Eosin (H and E) technique. At ante mortem examination 5(2.5%) of the cattle were found with gross lesions of besnoitiosis, 103 (19.8%) were diagnosed with dermatophilosis and 50 (9.7%) with tick infestation. Twenty-nine (29, 5.6%) cattle had both dermatophilosis and tick infestation. Histopathological examination confirmed that the 5 cattle clinically diagnosed with besnoitiosis really had cysts of B. besnoiti in skin sections. Four (4, 2.1%) additional cattle had similar cysts in their skin sections although they had no clinical signs of besnoitiosis. Three (3, 1.5%) of these had gross lesions of dermatophilosis and 1 (0.2%) had ticks on the body. Microscopic examination of crusts from the skin specimens confirmed the presence of filaments of D. congolensis. It was concluded that some cases of besnoitiosis may pass unnoticed at clinical examination where the skins are severely affected with dermatophilosis.
  S.B. Oladele , A.J. Nok , P. Abdu , H.M. Kazeem and K.A.N. Esievo
  Experiments were performed to determine some properties of neuraminidase of Newcastle Disease Virus (NDV) Kudu 113 strain, in order to deduce the possible effects of this enzyme on hosts cells during NDV infections in poultry; and to see how its properties are similar or different from neuraminidases of some viruses that have been previously characterized. The activity and properties of neuraminidase of NDV Kudu 113 strain were determined by periodate thiobarbituric acid assay method. Neuraminidase activity was detected in NDV Kudu 113 strain in vitro. The neuraminidase activity increased gradually from 24 h with the mean value of 101.4±2.8 µmol min 1 and attained its mean maximum activity of 167.2±5.4 µmol min 1 by 72 h post-inoculation into embryonated chicken’s eggs, after which the activity of the enzyme declined. The enzyme was precipitated at 55% by ammonium sulphate [(NH4)2SO4] saturation. The optimum pH and temperature of the enzyme were 5.5 and 40°C, respectively. The Michaelis constant (Km) and maximum velocity of reaction (Vmax) of this enzyme were 1.0×102 µmol L 1 and 3.03×10 4 µmol min 1, respectively. It was concluded that NDV Kudu 113 strain produced neuraminidase in vitro. The neuraminidase activity had a linear relationship with the dilution of the virus at higher serial dilutions. Neuraminidase of NDV Kudu 113 strain also cleaved sialic acid from fetuin (substrate) in vitro. It is likely that neuraminidase of this virus strain may cleave sialic acid from the surfaces of erythrocytes and other cells during in vivo NDV infections in poultry, thereby exposing the erythrocytes to destruction by reticulo-endothelial system.
  EOgwu , E.O. Oyedipe , K.Bawa , V.O. Sekoni , S.A.S. Olorunju , K.A.N. Esievo and D.V. Uza, D
  Three groups of pregnant Yankasa (YK) and West African Dwarf (WAD) ewes, made up of 6pregnant YK and 6 pregnant WAD ewes in each group, were assigned at random to first, second and third trimester of pregnancy, to study the clinical manifestation of. T. vivax infection at each trimester of pregnancy. A fourth group made up of 3 pregnant YK and 3 pregnant WAD ewes served as the non-infected controls for the study. Pre- infection mean rectal temperatures of the YK and WAD ewes were 38.6 Co and 38.7 Crespectively, while post-infection temperatures were as high as 41.5 C and 41.6 C for the YK and WAD ewes respectively. The infection was severe in the infected YK and WAD ewes in the second and third trimesters of pregnancy and most severe in YK than in the WAD ewes. The infected YK and WAD ewes exhibited pyrexia, signs of anaemia shown by pale mucus membrane, decrease in packed cell volume (PCV) values, decrease in total plasma protein (TP) values, weight loss, lethargy, dullness, abortions and death of ewes. The severity of the infection increased as the pregnancy advanced in the ewes. WAD ewes in the first trimester were least susceptible to the infection and self-cure was observed in one WAD ewe. The infected WAD ewes controlled the effects of the infection on abortions and mortality more than the YK ewes. It was concluded from the study that the trimester of pregnancy and breed of ewe influenced the clinical manifestation of T. vivax infection on pregnant YK and WAD ewes.
  E.K Bawa , V.O. Sekoni , D. Ogwu , K.A.N. Esievo and D.V. Uza
  The results of chemotherapy with the Trypanocidal drug Novidium, on the clinical manifestation ? of Trypanosoma vivax infected pregnant Yankasa (YK) and pregnant West African Dwarf (WAD) ewes was investigated. Three groups of pregnant YK and pregnant WAD ewes, comprising of 6 YK and 6WAD per group, were randomLy assigned to first, second and third trimesters of pregnancy and infected with T. vivax at each trimester. A fourth group comprising of 3 uninfected pregnant YK and 3 uninfected pregnant WAD ewes were the controls for the study. Two weeks post infection the infected ewes in each trimester period were divided into two equal groups of three ewes each. One group was treated with Novidium (Homidium chloride), ? at 1.0 mg kgG body weight, the other group remained untreated. Blood samples from the treated ewes were 1 negative for trypanosomes within 4 days post-chemotherapy. As the study progressed, clinical signs associated with trypanosomosis, such as anaemia indicated by low packed cell volume (PCV), loss in body weights, pyrexia and decline in total plasma protein (TP) values observed in the infected ewes, disappeared gradually following chemotherapy. Treatment had significant (p#0.05) positive effects on PCV values of the treated YK and WAD ewes in the third trimester, TP values of treated YK in the first and second trimester, body weight of treated YK ewes in the second trimester, TP values of treated WAD ewes in the first, second and third trimester and body weights of treated WAD ewes in the second and third trimesters. The trimester of pregnancy and breed of ewe influenced the results of Novidium chemotherapy on observed clinical parameters.?
  A.B.Ogunkoya , N.M. Useh and K.A.N. Esievo
  A study was conducted at the Ahmadu Bello University Veterinary Teaching Hospital (ABUVTH), Zaria, Nigeria to determine the effect of specific gastrointestinal (GI) parasites of dogs on the haemogram of such infected dogs. A total of 4214 (62.7 %) indigenous Nigerian dogs were presented to ABUVTH, Zaria, Nigeria between January, 1978 to December, 2000 with GI parasitism. The sick dogs were presented with the following clinical signs: Anorexia, post pandrial emesis, pale mucous membrane, dog bite, diarrhoea, bloody faeces, recumbency, straining during defaecation, emaciation, ascites, foaming in the mouth, worms in faeces, abortion, fever (39.8-41°C), inflamed eyes, lethargy, bloody discharge from the nose, abdominal pain and dullness. About 5469 (81.4%) of the dogs presented were males, while 1252 (18.6%) were females. The GI parasites encountered in this study include: hookworms (n=4107 or 61.1%), tapeworms (Dipylidium caninum) (n = 1042 or 15.5%), Ascarids (Toxocara canis and Toxacara leoninae) (n = 605 or 9%) and 289 (4.7%) were unidentified. The multiple infections observed in the study include: hook worm and tapeworms (n = 2352 or 35%), hookworm and coccidia oocysts (Isospora spp.) (n = 1385 or 20.6%), hookworm and Toxocara spp (n = 1028 or 15.3%). There was leucocytosis and eosinophilia in infected dogs and the contribution of each parasite to the blood picture is discussed. Also, the public health significance of the parasites encountered is discussed.
  S. Adamu , M.Y. Fatihu , N.M. Useh , N.D.G. Ibrahim , M. Mamman , V.O. Sekoni and K.A.N. Esievo
  In order to investigate whether testicular pathologic changes reported in trypanosome-infected animals are related to declining testosterone concentrations or not, four White Fulani bulls (infected group) with similar ages and weights were infected with Trypanosoma vivax (T. vivax), Kudaru stock, by inoculating each, intravenously, with 2 mL of blood from an infected donor calf containing 2×106 T. vivax organisms. Three other White Fulani bulls, with ages and weights similar to those of the infected group, which were uninfected, served as control group. Blood samples were collected from animals in the two groups before and after the infection to determine Packed Cell Volume (PCV) and serum testosterone profile. To carry out histopathological studies on the testes and other organs in the body of these animals, one bull from the infected group was sacrificed on day 14 Post-Infection (PI), while two bulls (one each from the infected and control groups) were sacrificed, each, on days 28, 56 and 84 PI. All animals in the infected group were parasitaemic by day 6 PI. This was followed by a gradual and progressive decrease in the values of Packed Cell Volume (PCV) and serum testosterone concentrations in these animals. PI values of these parameters in the control group remained normal relative to the pre-infection ones. The mean PI testosterone concentrations, measured in ng mL 1, in individual bulls of the infected group sacrificed on days 14, 28, 56 and 84 were 9.6±4.2, 7.8±3.7, 4.9±4.1 and 5.0±3.4, respectively. Histopathologically, severe testicular degeneration was observed in all animals in the infected group characterized by necrosis and depletion of the spermatogenic and sertoli cells in the seminiferous tubules. Leydig cells in the interstitial tissues of the testes were also severely degenerated. Severity of the lesions was related to serum testosterone concentrations as testicular degeneration was progressive from the bull that was sacrificed on day 14 PI moving through to the bull that was sacrificed on day 56 PI which had the least mean PI testosterone concentration and in which both spermatogenic and sertoli cells had undergone karyolysis and so were completely depleted. In contrast, testes of bulls in the control group were normal as both seminiferous tubules and interstitial tissues of the testes contained full complement of the spermatogenic and Leydig cells, respectively. It is concluded from this study that lowering testosterone concentration may be an aggravating factor to the degenerative changes observed in the testes of trypanosome-infected male animals.
  S.A. Shehu , N.D.G. Ibrahim , K.A.N. Esievo and G. Mohammed
  Neuraminidase activity was determined during experimental Trypanosoma evansi infection in Savannah Brown bucks. There was significant (p<0.05) increase in the activity of sialidase on day 7, 9, 21, 23, 27, 33 and 37 post-infection. Increase in sialidase activity coincided with gradual decline in mean erythrocyte surface sialic acid concentrations occuring 5 days post-infection. There were significant difference (p<0.05) in mean erythrocyte surface sialic acid between the infected and control groups on day 5 and between days 17 to 27 post-infection. A significant (p<0.05) increase in free serum sialic acid concentrations was observed on days 15, 17 and 27 when compared to the control group. All infected bucks developed trypanosomosis, with significant decreases in mean packed cell volume to as low as 19.50±2.12% occurring at day 33 post-infection which was significantly lower than the control value of 26.75±0.96. Mean haemoglobin concentrations also declined in the infected bucks with marked drop of 6.50±0.70 g dL-1 on day 33 post-infection and was significantly different (p<0.05) from the uninfected (control) group (8.53±0.46 g dL-1). The anaemia caused during infection may be attributable to the activities of the circulating trypanosomes, which produce sialidase (neuraminidase) that resulted in the cleaving off erythrocyte surface sialic acid, rendering such red blood cells more prone to phagocytosis in the reticuloendothelial system.
  J.S. Neils , E.O. Balogun , A.K.B. Sackey , U.S. Abdullahi and K.A.N. Esievo
  The concentration change of pyruvate was studied in serum of uninfected and infected sheep with T. congolense. In the uninfected, the mean concentration of 61.23-76.63 mg L-1 of pyruvate was determined using the DNS method. There was a depressed concentration of pyruvate in the two infected groups (A and B); pyruvate level fell to 25.7 mg L-1 in gp A that was treated immediately after the first peak of parasitaemia while in gp B, the concentrations continued to fall (5.2 mg L-1) until the termination of the experiment. The fall might have been as a result of the utilization of the pyruvate by either the host or its conversion to other compounds. It is therefore concluded that animals use the pyruvate or its converted to another compound during trypanosome infection. The decrease in pyruvate levels may be a possible cause of weakness and eventual death in infected animals.
  S.F. Ambali , M. Mamman , A.O. Adaudi , K.A.N. Esievo , J.O. Ayo and M.S. Abubakar
  The aim of this study is evaluate the curative and protective effects of penicillin G in mice poisoned with the lyophilized extract of Chlorophyllum molybdites. Fifty Swiss albino mice were divided into 5 groups of 10 mice each. Mice in group 1 were pretreated with penicillin G at 38, 280 IU kg-1, i.p. and then dosed with LD99 of C. molybdites (741 mg kg-1) i.p., mice in group 2 were dosed with the extract and then treated with penicillin G, while mice in group 3 were dosed with the extract only. Mice in groups 4 and 5 were dosed with penicillin G and physiological saline solution, respectively. The mice were monitored for clinical signs of toxicity, pathological lesions and death over a period of 72 h. The mean time of death in mice from penicillin-treated groups 1 and 2 were compared with those in the extract-treated group using one-way analysis of variance (ANOVA) and values of p<0.05 were considered significant. The result showed a significant reduction in the severity of clinical signs and mortality in penicillin-treated groups 1 and 2 compared to the group dosed with only the extract. There was a significant difference in the mean time of death in mice from groups 1, 2 and 3. However, there was no reduction in the severity of lesions in mice from groups 1 and 2 treated with penicillin G compared with extract-treated group. Therefore, this study has shown that penicillin G has significant curative and protective effects in mice poisoned with the lyophilized extract of C. molybdites. This result may prove useful in the treatment of humans and animals suffering from C. molybdites poisoning.
  F.S. Sanni , S. Ibrahim , K.A.N. Esievo and S. Sanni
  The anti-anaemic effect of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia was carried out in rats. Induction of anaemia was conducted using phenylhydrazine hydrochloride at a dose of 750 mg kg-1 body weight. In vivo investigation showed that oral daily dose of 300 mg kg-1 body weight of the bark aqueous extract of K. senegalensis in rats administered simultaneously with the phenylhydrazine produced significant (p<0.05) anti-anaemic effect probably by protecting the red blood cells against destruction by phenylhydrazine. However, the same oral dose did not show any significant curative effect (p>0.05) after the induction of anaemia using phyenylhdrazine hydrochloride. The phytochemical screening of the aqueous extract of the stem bark of K. senegalensis indicate the presence of carbohydrate, saponin, glycosides and tannins. Also present are important mineral elements necessary for the development and functioning of the body. These include calcium, magnesium, zinc, iron, copper, potassium, and sodium. This study showed that Khaya senegalensis has an anti-anaemic effect.
  S.A. Shehu , N.D.G. Ibrahim , K.A.N. Esievo and G. Mohammed
  The pathology of experimental Trypanosoma evansi infection in Savannah Brown buck was studied using an isolate obtained from the blood of an infected camel slaughtered at Kano Abattoir, Nigeria. Gross pathological lesions observed included pale carcass with hydro peritoneum, generalized atrophy of the body fats, catarrhal enteritis, hepatomegally with bilaterally congested kidney, congested lungs with red hepatization of the liver. Histopathological lesions observed in the infected Savannah Brown buck included Zenkers necrosis of the myocardium with few mononuclear cellular infiltrations, focal areas and centrilobular necrosis of the liver, hemosiderin-laden macrophages involving the spleen and lymph nodes. There were degenerated seminiferous tubules and degenerated spermatids in the duct of the epididymis. The results of this study showed that the T. evansi isolate is pathogenic to the Savannah Brown buck.
  S. Adamu , I.T. Adebayo , N.M. Useh , M. Bisalla , S.J. Sambo and K.A.N. Esievo
  In a study to determine the occurrence evidences of impairment of kidney function in cattle, urine specimens were collected from 135 emaciated cattle, made up of 70 bulls and 65 cows and analyzed chemically for urinary constituents using reagents strip. Results obtained indicated that abnormal values of pH, glucose, bilirubin, specific gravity, erythrocyte, protein, Urobilinogen, nitrite, leukocyte and ketones occurred at prevalence rates of 10.4, 3.7, 15.6, 27.4, 11.1, 30.4, 1.5, 14.1, 13.3 and 20%, respectively. Abnormal values of these parameters were found to occur more in the males than in females except for values of glucose, specific gravity and ketones in which the reverse was the case. It was recommended from this study, that since the abnormal values of most of the constituents evaluated in the urine of these animals were suggestive of the existence of disorders that could impair with renal function, an in-depth study to identify the specific disorders and their aetiologic factors be conducted so that effective control and preventive measures could be designed and effected to curtail the menace of the diseases in cattle livestock.
  S.B. Oladele , P. Abdu , A.J. Nok , N.D.G. Ibrahim and K.A.N. Esievo
  Twenty-five Shaver Brown chickens were inoculated intramuscularly at 4 weeks with Newcastle Disease Virus (NDV) Kudu 113 strain. Another 25 chickens served as controls. Values of neuramindase activity (NA), free serum sialic acid (FSSA), erythocytes surface sialic acid (ESSA), packed cell volume (PCV) and haemagglutination inhibition (HI) antibody titres to NDV were determined for each chicken. The infected chickens had clinical signs due to newcastle disease (ND) by day three post-infection (pi). Mortality and morbidity were 52 and 100%, respectively. The major gross lesions observed in the infected chickens were haemorrhages in the proventricular mucosa, the caecal tonsils and the mucosal layer of the intestine. There was a significant decrease in daily mean values of PCV from days 3-7 pi in the infected chickens. This period coincided with the time of elevated values of HI anitibody titre, NA, FSSA and a decrease in ESSA.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility