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Articles by Julian Schulze zur Wiesch
Total Records ( 1 ) for Julian Schulze zur Wiesch
  Victoria Kasprowicz , Julian Schulze zur Wiesch , Thomas Kuntzen , Brian E. Nolan , Steven Longworth , Andrew Berical , Jenna Blum , Cory McMahon , Laura L. Reyor , Nahel Elias , William W. Kwok , Barbara G. McGovern , Gordon Freeman , Raymond T. Chung , Paul Klenerman , Lia Lewis-Ximenez , Bruce D. Walker , Todd M. Allen , Arthur Y. Kim and Georg M. Lauer
  We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
 
 
 
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