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Journal of Virology

Year: 2008  |  Volume: 82  |  Issue: 6  |  Page No.: 3154 - 3160

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

Victoria Kasprowicz, Julian Schulze zur Wiesch, Thomas Kuntzen, Brian E. Nolan, Steven Longworth, Andrew Berical, Jenna Blum, Cory McMahon, Laura L. Reyor, Nahel Elias, William W. Kwok, Barbara G. McGovern, Gordon Freeman, Raymond T. Chung, Paul Klenerman, Lia Lewis-Ximenez, Bruce D. Walker, Todd M. Allen, Arthur Y. Kim and Georg M. Lauer

Abstract

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

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