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Articles by Jing Yang
Total Records ( 5 ) for Jing Yang
  Jing Yang , Hua Jiang and Honglei Zhang
  The quality of teaching assistants’ work is important to students' education and inclusion, so it is of significance to evaluate and improve the performance of teaching assistants. Support vector machines with appropriate parameters may provide good tools for enhancing the recognition accuracy. Some basic knowledge on support vector machines was firstly introduced; then the paper applied the teaching assistant evaluation data set to examine the recognition effects of SVMs with default and chosen parameters, showing that different parameters may produce different evaluation results. Cross validation method and particle swarm optimization were respectively applied to optimize the parameters of support vector machines, both of which enhanced the recognition accuracy. Finally, conclusions and recommendations were given.
  Jing Yang , Xiangang Cai , Tao Song , Yongjun Chen , Hui Chen , Pan Wu and Congxin Huang
  Adipose-derived Stem Cells (ASCs) have great potential in the field of tissue engineering. There is evidence that human ASCs from different depots of adipose tissue may produce different characteristics. Canine is a large and important animal model for human diseases which has led to interest in the isolation and characterization of canine ASCs. Canine Adipose tissue derived mesenchymal Stem Cells (cASCs) also have been shown to possess the proliferation and multi-differentiate capacity. The main goal of this research was to compare the proliferation capacity, phenotypes, apoptosis susceptibility, differentiation capacity and gene transfection efficiency of cASCs obtained from different depots (superficial abdominal, hip, thigh, dorsal and inguinal) of subcutaneous adipose tissue. The proliferation rate of cASCs from abdominal and hip subcutaneous adipose tissue were higher than other depots. cASCs from abdominal subcutaneous adipose tissue had higher capacity to differentiate into adipogenic lineages than other depots. However, cASCs from dorsal subcutaneous adipose tissue had the highest capacity to differentiate into Osteogenic lineages among all depots. Regarding to the cardiomyogenic differentiation, the results showed that there was no differences among cASCs from different subcutaneous adipose tissue. Apoptosis susceptibility was demonstrated to be lowest in the superficial abdominal depot. In conclusion, proliferation, differentiate capacity and sensitivity to apoptosis of cASCs were linked to anatomic subcutaneous adipose tissue depots whereas there were no significant differences in the expression of surface antigens and gene transduction efficiency.
  Yonggang Zuo , Zhuxin Li , Jun Chen , Jing Yang and Jianyong Yang
  The mobility and security of petroleum tanker is influenced directly by the effect of the fixation between the chassis and truck tank. The butt-joint technology of the chassis and the truck petroleum tank is studied in this study and one new torsion-free-body is designed. The 3D model of the torsion-free-body is established by Pro/E and imported into ADAMS and the dynamic simulation analysis of the complex stress point of the torsion-free-body is done by ADAMS, the new torsion-free-body of truck tanker by rebuilding chassis is tested, experiment results show that its effect of reducing torque is very good.
  Jing Yang , Chaitanya Jain and Kurt Schesser
  Yersinia spp. use a type 3 secretion system (T3SS) to directly inject six proteins into macrophages, and any impairment of this process results in a profound reduction in virulence. We previously showed that the exoribonuclease polynucleotide phosphorylase (PNPase) was required for optimal T3SS functioning in Yersinia pseudotuberculosis and Yersinia pestis. Here we report that Y. pseudotuberculosis cells with reduced RNase E activity are likewise impaired in T3SS functioning and that phenotypically they resemble Δpnp cells. RNase E does not affect expression levels of the T3SS substrates but instead, like PNPase, regulates a terminal event in the secretion pathway. This similarity, together with the fact that RNase E and PNPase can be readily copurified from Y. pseudotuberculosis cell extracts, suggests that these two RNases regulate T3SS activity through a common mechanism. This is the first report that RNase E activity impacts the T3SS as well as playing a more general role in infectivity.
  Li-Peng Wu , Xi Wang , Lian Li , Ying Zhao , Shaoli Lu , Yu Yu , Wen Zhou , Xiangyu Liu , Jing Yang , Zhixin Zheng , Hui Zhang , Jingnan Feng , Yang Yang , Haiying Wang and Wei-Guo Zhu
  Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. Here, we report that an HDAC inhibitor, depsipeptide, exhibited significant demethylating activity on the promoters of several genes, including p16, SALL3, and GATA4 in human lung cancer cell lines H719 and H23, colon cancer cell line HT-29, and pancreatic cancer cell line PANC1. Although expression of DNA methyltransferase 1 (DNMT1) was not affected by depsipeptide, a decrease in binding of DNMT1 to the promoter of these genes played a dominant role in depsipeptide-induced demethylation and reactivation. Depsipeptide also suppressed expression of histone methyltransferases G9A and SUV39H1, which in turn resulted in a decrease of di- and trimethylated H3K9 around these genes` promoter. Furthermore, both loading of heterochromatin-associated protein 1 (HP1α and HP1β) to methylated H3K9 and binding of DNMT1 to these genes` promoter were significantly reduced in depsipeptide-treated cells. Similar DNA demethylation was induced by another HDAC inhibitor, apicidin, but not by trichostatin A. Our data describe a novel mechanism of HDACi-mediated DNA demethylation via suppression of histone methyltransferases and reduced recruitment of HP1 and DNMT1 to the genes` promoter.
 
 
 
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