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Articles by Jing Leng
Total Records ( 2 ) for Jing Leng
  Li-Chun Zhao , Ying Liu , Zi Wang , Nong Tang , Jing Leng , Bing Zheng , Ying-Ying Liu and Wei Li
  Background and Objective: Platycodi Radix (PR), a famous traditional medicine and folk food, has been used in China. PR exerted numerous pharmacological activities including anti-tumor, anti-obesity and anti-inflammation. The present study aimed to investigate the active constituents by Liquid Chromatography/Mass Spectrometry (LC/MS) analysis and protective effects of saponins from the steamed Platycodi Radix (SSPR) on acute alcohol-induced liver injury in mice. Materials and Methods: Pretreatment with SSPR (100, 200 and 400 mg kg–1) prior to alcohol administration significantly prevented the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TG) in serum, malondialdehyde (MDA) level in liver tissue compared with the alcohol group (p<0.05). Results: The level of enzymatic antioxidants glutathione (GSH) was increased noticeably (p<0.05) in SSPR pretreatment mice liver tissue. Histopathological examination revealed that pretreatment with 400 mg kg–1 of SSPR markedly ameliorated acute alcohol-induced hepatocyte apoptosis and fatty degeneration. The findings from LC/MS analysis indicated that SSPR had more saponins than unheated-processed one and SSPR mainly contain a polyacetylene (Lobetyolin) and 22 saponins. Conclusion: These results showed the beneficial effect of SSPR on acute alcohol-induced oxidative stress and liver damage.
  Jinlong Huo , Pei Wang , Jing Leng , Hailong Huo , Lixian Liu , Yue Zhao , Rui Wang and Yangzhi Zeng
  The complete CDS sequence of Banna Mini-pig Inbred Line (BMI) gene STXBP6 was amplified using the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) based on the conserved sequence information of the rat, mouse or other mammals and known highly homologous swine ESTs. This novel gene was then deposited into NCBI database and located on Chromosome 7 of pig and assigned to accession number JF750402. Sequence analysis revealed that the BMI STXBP6 encodes a protein of 210 amino acids that has high homology with the Syntaxin Binding Protein 6 (STXBP6) of four other species rat (100%), mouse (99%), cattle (99%) and human (99%). The phylogenetic tree analysis revealed BMI STXBP6 has a closer genetic relationship with the rat STXBP6 than with those of mouse, cattle and human. Analysis by RT-PCR showed that BMI STXBP6 gene was over-expressed in lung, moderately expressed in midbrain, ovary, diencephalon, spleen, nerve fiber, stomach, small intestine, large intestine, skin, muscle and fat, weakly expressed in kidney and heart and almost not expressed in lymph node, cerebrum, liver and pancreas. The experiment will establish a foundation for further insight into this swine gene.
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