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Articles by J. Hong
Total Records ( 3 ) for J. Hong
  W. Gu , Y. Huang , Y. Zhang , J. Hong , Y. Liu , W. Zhan , G. Ning and W. Wang
 

Aim

To compare the carotid intima-media thickness in patients with newly diagnosed Type 1 or Type 2 diabetes ranging from 14 to 30 years of age.

Methods

Demographic, anthropometric and laboratory data were obtained from 404 adolescents and young adults (103 subjects with Type 1 diabetes, 94 with Type 2 diabetes, 153 obese subjects and 54 normal control subjects). Carotid intima-media thickness was assessed based on Doppler ultrasound examination and compared among the four groups.

Results

Our data showed significant increases in carotid intima-media thickness in subjects with Type 1 diabetes, Type 2 diabetes and obese subjects compared with the control subjects, with those in the group with Type 2 diabetes demonstrating the greatest change (P < 0.001). Age, BMI, percentage of fat, waist-hip ratio and total triglycerides were significantly correlated with both common and internal carotid intima-media thickness segments. From a stepwise multiple linear regression model, the independent determinants of common carotid intima-media thickness were age, BMI, HbA1c and HDL cholesterol (adjusted R2 = 0.152, P < 0.001). After adjustment for age, sex and HbA1c, the odds ratio for increased carotid intima-media thickness was 1.67 (95% CI 1.19-2.33, P = 0.003) for obese subjects, 2.38 (95% CI 1.59-9.47, P = 0.001) for subjects with Type 1 diabetes and 3.93 (95% CI 1.90-6.07, P = 0001) for subjects with Type 2 diabetes compared with the control subjects.

Conclusions

Compared with young control subjects, we found significant increases in carotid intima-media thickness in patients with newly diagnosed Type 1 diabetes and Type 2 diabetes, with patients with Type 2 diabetes showing greater carotid intima-media thickness. Traditional cardiovascular risk factors, such as obesity, dyslipidaemia, hypertension and hyperglycaemia, could cause vessel changes even in adolescents and young adults.

  G.S. Hu , G.B. Chang , Y. Zhang , J. Hong , Y. Liu and G.H. Chen
  The present research was to study the association of polymorphism of Natural resistance-associated macrophage protein1 (Nramp1) with some immune functions in Rugao chicken (RG) and Recessive White chicken (RW). The PCR-SSCP technique was applied to analyze the correlation between the polymorphisms of Nramp1 gene and immune functions (Heterophil/Lymphocyte (H/L), lymphocyte transformation rate and the content of IgM) in 72 RG and 55 RW. The results showed that: the Heterophil/Lymphocyte (H/L), lymphocyte transformation rate and the content of IgM in RG and RW showed significant differences (p<0.05). H/L of AA was significantly lower than BB and AB while the AA’s lymphocyte transformation rate and IgM were significantly higher than the BB’s in both RG and RW. The results demonstrated that the general immune performances of RG were superior to those of RW. The general immune performances of AA were superior to BB and AB.
  J. Hong , J.G. Dai , W.T. Guan , G. Jin , Zh.L. Huang , L.J. Zhang , J. Zh. Dang and Y. Zhang
  Tachyplesin I is a 17 amino acid cationic antibacterial peptide with a typical cyclic antiparallel β-sheet structure. It is not clear whether tachyplesin I can induce resistance in bacteria. Therefore, two selection procedures by gradually increasing the induction concentration of tachyplesin I were performed to determine whether tachyplesin I could induce resistance in Escherichia coli and Staphylococcus aureus in vitro. The results showed that tachyplesin I did not induce resistance in Escherichia coli ATCC25922, F41 and Staphylococcus aureus ATCC25923 in this study whereas high resistance to benzylpenicillin was induced using the same procedures in Staphylococcus aureus ATCC25923. Furthermore, no cross-resistance between tachyplesin I and benzylpenicillin was observed. It is suggested that tachyplesin I may be a safe antibacterial agent for future use in clinical practice.
 
 
 
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