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Articles by J Schuman
Total Records ( 1 ) for J Schuman
  G Fu , Y Chen , M Yu , A Podd , J Schuman , Y He , L Di , M Yassai , D Haribhai , P. E North , J Gorski , C. B Williams , D Wang and R. Wen
 

Phospholipase C1 (PLC1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLC1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLC1. We demonstrate that PLC1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-B. Importantly, PLC1 deficiency impairs the development and function of FoxP3+ regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLC1 is essential for T cell development, activation, and tolerance.

 
 
 
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