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The Journal of Experimental Medicine

Year: 2010  |  Volume: 207  |  Issue: 2  |  Page No.: 309 - 318

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

G Fu, Y Chen, M Yu, A Podd, J Schuman, Y He, L Di, M Yassai, D Haribhai, P. E North, J Gorski, C. B Williams, D Wang and R. Wen

Abstract

Phospholipase C1 (PLC1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLC1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLC1. We demonstrate that PLC1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-B. Importantly, PLC1 deficiency impairs the development and function of FoxP3+ regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLC1 is essential for T cell development, activation, and tolerance.

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