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| Articles
by
I.A. Dauran |
Total Records (
2 ) for
I.A. Dauran |
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A. Garba
,
S.B. Mada
,
G. Ibrahim
,
M.M. Abarshi
,
I.A. Dauran
and
A.B. Hamza
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The hepatoprotective effect of Ethyl Acetate Extract of Vitex doniana
(EAEVD) stem bark on carbon tetrachloride (CCl4) induced hepatic damage was
studied, to evaluate some biochemical parameters, to determine the in vitro
antioxidant effect of the extract on Superoxide Dismutase (SOD), Catalase (CAT)
glutathione peroxidase (GPX) and glutathione-s-transferase (GST) and to quantify
the levels of some phytochemicals present in EAEVD stem bark. A total of twenty
four Rats were used for the study. Animals in group1 served as vehicle control,
Group 2 served as hepatotoxin (CCL4) treated group, Group 3 served
as positive control (Sylimarin) treated group, Group 4 was administered with
100 (mg kg-1 b.wt.) of the extract and group 5 was administered with
200 (mg kg-1 b.wt.) of the extract After the experimental period
of 14 days. The animals were sacrificed, blood and liver samples were collected
and used for the evaluation of the following biochemical parameters Aspartate
amino transferase (AST), Alanine amino transaminase (ALT) and Alkaline phosphatase
(ALP) in serum, as well as thiobarbituric acidreactive substances (TBARS), lipidhydroperoxides
superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPX) and
glutathione-s-transferase (GST) in the liver. Administration of 100 and 200
mg kg-1 b.wt. (EAEVD) significantly decreased (p<0.05) AST, ALT,
ALP TBARS and lipid hydroperoxides with a significant increase (p<0.05) in
the levels of SOD, CAT, GPX and GST in in group 4 and 5. Twenty five mg kg-1
b.wt. sylimar in was used as standard, The results show that the oral administration
of EAEVD plant prevents the progression of hepatic damage in Ccl4
treated wistar albino rats and suggest that the extract could be effective in
the management of liver problems. |
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A. Garba
,
S.B. Mada
,
G. Ibrahim
,
I.A. Dauran
and
A.B. Hamza
|
| |
The hypoglycemic and hypolipidemic effects of methanolic extract of Stachytarpheta
angustifolia (MESA) were evaluated in Streptozotocin (STZ) induced diabetes
in albino rats. The rats were treated with 1000 and 1300 mg kg-1
b.wt. (mg kg-1 b.wt.) of MESA for 28 days. The changes in body weight
and fasting blood glucose level were measured in 5 days interval. After experimental
period of 28 days, rats were sacrificed by cervical decapitation, blood sample
was collected and the following biochemical parameters plasma glucose, total
hemoglobin, glycosylated hemoglobin, Glucose 6 phosphatase (Glc 6-phosphatase),
lipid Peroxides (LPO), triacylglycerols, cholesterol, LDL-cholesterol and HDL-cholesterol,
were estimated. Administration of MESA to STZ-induced diabetic rats caused a
significant decrease (p<0.05) in the levels of plasma glucose, glycosylated
hemoglobin, Glc 6-phosphatase, LPO, triacylglycerols, cholesterol, LDL-cholesterol
with a significant increase (p<0.05) in bodyweight, plasma insulin and HDL-cholesterol
level Glibenclamide 600 μg kg-1 b.wt. was used as standard in
this study. These results show that the oral administration of MESA plant prevents
the progression of Diabetes-associated symptoms in STZ induced diabetic albino
rats and suggest that MESA could be useful in the management of diabetes mellitus. |
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