Abstract: In the present study, some cellular and crystalline components of urine of Sickle Cell Anemia (SCA) were studied. In total 67 samples were investigated. The normal and abnormal cellular components like presence of Red blood cells, White blood cells Epithelial cells, Renal tubules cells, Bacteria, Yeast and Protozoan were observed and counted. Noncellular components/crystals like Tyrosine, Cholesterol, A/T Phosphate, Leucine, B-Granule, Uric Acid, Oxalate and Cystine were counted. It was observed that RBCs, WBCs and Epithelial cells, Renal tubules cells, Bacteria, Yeast and Protozoan were in high number indicating various complications occurring in the body of sickle cell anemic patients. It was observed that RBCs were 13918.18/cumm±SE 4057.90 indicating tremendous hematourea, number of WBC were 224.59±50.002 SE, Sqaumous Epithelial cells were 35.68±10.989 SE, Renal cells were 110.68±74.15 SE. This indicates that SCA patients suffer from kidney damage, hematourea, Urinary Tract Inflammation, Interstitial nephritis, Glomerulonephritis and Pylonephritis.