Abstract: Ossification of the Posterior Longitudinal Ligament (OPLL), is associated with various degree of neurological deficit. Anterior approach allows direct removal of ossified posterior longitudinal ligament through corpectomy and allows sufficient decompression of the spinal cord. The aim of the study is to evaluate the effectiveness and safety of median cervical corpectomy for management of cervical myelopathy associated with ossification of the posterior longitudinal ligament. In the period between May 2009-Aug. 2011, thirty patients were managed by median cervical corpectomy/corpectomies and bone fusion with anterior plate system fixations; in Neurosurgery Department Al-Azhar University Hospitals. They were 19 males and 11 females with the age range from 35-65 years and the mean age was 50 years. The duration of symptoms ranged from 3-36 months with the mean of 20 months. The most common complaints were paresthesia or numbness of the hands and the most common presenting signs were hyperesthesia, gait disturbance, weakness and hyperreflexia the most common type of OPLL was the mixed type in 16 patients (53.330). as regard to Magnetic Resonance Image (MRI) classifications of OPLL, the tear drop was the most common type in 15 patients (50%). Postoperative complications occurred in 7 patients (23.33%). In this study, the recovery rate by Hirabayashi formula was ranged from 25-100% with the mean 69.96±16.89%, in mixed type of OPLL the recovery rate ranged from 25-100% (Mean 65.33±17.38%), in continuous type it ranged from 42.86-100% (Mean 70.24±18.30%) and in segmental type it ranged from 71.42-100% (Mean 80.27±10.33%). Anterior corpectomy with resection of the ossified mass, followed by fusion, is a radical surgical procedure. It is best indicated for cervical spondylotic myelopathy with OPLL that extends fewer than three vertebral levels, in patient with no congenital stenosis or trauma.