INTRODUCTION
Ossification of the Posterior Longitudinal Ligament (OPLL) is a hyperostotic
progression of the Posterior Longitudinal Ligament (PLL) that is associated
with various degrees of neurological deficit. OPLL was considered specific to
Asians, however it is recognized as a subtype of diffuse idiopathic skeletal
hyperostosis. Patients have various degrees of neurological deficits; however
the thickness or progression of ossification is not always proportional with
the degree of neurological disorder (Yang, 2007).
Cord compression involves both of the mid -vertebral as well as to the vertebral
endplate levels. Good decompression and outcome are difficult to obtained with
anterior discectomy performed through the disc space (Mizuno
and Nakagawa, 2001).
Precise radiological evaluation leads to correct diagnosis and treatment. In
Plain X ray films, the symptomatic myelopathy increase with canal diameter less
than 10 mm, while in the relative cervical stenosis the canal diameter between
10-13 mm. When the “occupation ratio” is greater than 40% as defined
by the thickness of OPLL divided by the canal diameter more severe deficits
appear earlier. However in Magnetic Resonance Imaging (MRI) early OPLL appears
slightly hyperintense on MRI without contrast administration and is enhanced
homogeneously with Gadolinium Diethylenetriamine penta acetic acid. Compared
with disc herniation, which are uniformly hypointense, mature OPLL appears densely
hypointense on both T1- and T2-weighted images (Epstein,
2002). Three patterns of dural ossifications of posterior longitudinal ligaments:
isolated, double layer and en block type (Mizuno et
al., 2005).
In Computed Tomography (CT) evaluations, early OPLL may contain punctate or
pearls of ossification and these centers will progressively coalesce as maturation
occurs. The four types of OPLL include: the segmental form, the continuous form,
the mixed form and localized form (Epstein, 2002).
Laminectomy was previously performed for extensive ossification but laminoplasty
is conducted to preserve posterior support for the spinal column and to prevent
postoperative kyphosis. Anterior decompression and fusion are performed too
(Matsunaga et al., 2004).
Sufficient decompression of the spinal cord will not be obtained with surgeries
from the posterior approach (Fujiyoshi et al., 2008).
So anterior approach should allow direct removal of OPLL compressing the spinal
cord to achieve good outcomes (Mizuno and Nakagawa, 2001).
The Aim of the study is to evaluate the effectiveness and safety of median
cervical corpectomy for management of cervical myelopathy associated with ossification
of the posterior longitudinal ligament.
MATERIALS AND METHODS
This prospective study conducted on 30 patients with cervical myelopathy associated
with OPLL managed by median cervical corpectomy in neurosurgery department,
Al-Azhar university hospital through the duration from May 2009 to August 2011.
Inclusion criteria: Cervical Spondylotic Myelopathy (CSM) associated
with OPLL involving the cervical spine from C3-C7.
Exclusion criteria: Previous cervical spine surgery, fractured cervical
spine; patients with poor motor power (grade 2 or less). All the cases were
subjected to the following management schedule: Detailed history taking, Full
general and neurological examination, Complete radiological evaluation by plain
x-ray cervical spine (AP and Lateral), cervical CT with 3-D reconstruction and
MRI, Operative preparation. Surgical procedure Follow up, clinical and radiological.
Examination: General examination: The patients look: normal, debilitated,
toxic or others. Vital signs: Pulse, Blood Pressure (BP), Respiratory Rate (RR)
and Temperature. Indirect laryngoscopy the day before surgery by specialist
of otolaryngologist must be done to assess the vocal cords.
Neurological examination including: Cranial examination: Spinal examination:
Inspection, Palpation and Dynamic examination Motor power, Muscle tone and Sensory
(Superficial and Deep) reflexes. Benzel modification of Japanese Orthopedics
Association Score (BmJOA) for all patients.
Routine laboratory works up
Radiological studies: Plain X-ray Anteroposterior (A-P) and lateral views;
CT cervical spine with three D reconstruction and MRI cervical study were carried
out to all patients.
Data to be obtained from radiological studies:
| • |
Cervical curve using regional angle and local Cobb’s
angle |
| • |
Types of OPLL |
| • |
Types of any associated disc prolapse (central or postero-lateral, far
lateral, or foraminal) |
| • |
Associated dural ossification (DO) or ossification of ligamentum flavum
(OLF) |
| • |
Signal changes of the cervical cord |
Follow up
Clinical: All patients undergo general and neurological evaluation monthly
for six months postoperative:
| • |
Monthly recorded of BmJOA scores for six months duration |
| • |
Recovery rates were done for all patients by Hirabayashi formula 6 months
post-op |
Radiological: Plain x-ray and CT three D reconstructions and MRI study
after six months postoperatively.
Plain x-ray and CT three D reconstructions and MRI study after six months postoperatively.
Statistical analysis: All data were stored on a personal computer and
analyzed using commercially available statistical software (SPSS version 16.0,
SPSS Inc.). Chi-Square analyzing was used to compare categorical data (qualitative).
The student t-test was applied to compare quantitative data significance was
judged at a value of p<0.05 for all analyses.
RESULTS
This study included 30 patients with cervical spondylotic myelopathy associated
with OPLL treated by anterior cervical corpectomy/corpectomies and bone fusion
(ACCF) with anterior plate system fixation. There was 19 males (63.33%) and
11 females (36.66%) with female to male ratio 1:1.73. The age of the patients
ranged from 35-65 years with greatest incidence was in the 5th decade of life.
The mean age was 48.93 years. The duration of symptoms in the studied patients
ranged from 3-36 months with mean duration of 12±10.11 months. The most
common presenting complaint of the patients were paresthesia or numbness of
the hands, sphincteric dysfunction and difficulty in walking that were found
in all patients (100%). Motor dysfunction was also present on all patients.
(Table 1). Pre-op Bm JOA scores were ranged from 4-17 with
the mean 11.43±2.56. Incontinuous type of OPLL, pre-op Bm JOA scores
were ranged from 8-15 with the Mean 11.57±2.44. In segmental type of
OPLL, pre-op Bm JOA scores were ranged from 9-17 with the Mean 14.14±2.41.
In mixed type of OPLL, pre-op Bm JOAscores were ranged from 4-14 with the Mean
11.06±2.74.
| Table 1: |
Most common presenting symptoms in this study |
 |
| Table 2: |
Most common signs in this study |
 |
| ++: Normoreflexia, +++: Hyperreflexia |
Pre-op Bm JOA scores difference between continuous, segmental and localized
types of OPLL was insignificant p value of 0.654.
In this study, pre-op Nurick grading were ranged from 2-5 with the Mean 3.23±0.68.
Pre-op Nurick grading difference between continuous, segmental and mixed types
of OPLL was insignificant p value of 0.454.
In continuous type of OPLL, the mean of pre-op Nurick grading was 3.14±0.69.
In segmental type of OPLL, the mean of pre-op Nurick grading was 3.00±0.58.
In mixed type of OPLL, the mean of pre-op Nurick grading was 3.38±0.72.
The most common presenting sign of the patients was hyperthesia, gait disturbance
and weakness that were found in 30 patients (100%). The second most common sign
was hyperreflexia that was found in 29 patients (96.66%) (Table
2).
The most common type of OPLL found in this study was the mixed type 16 patients
(53.33%), followed by both continuous in 7 patients (23.33%) and segmental type
in 7 patients (23.33%). There was no patient with localized type of OPLL.
By axial MRI and CT, in this study, OPLL were classified into 3 types; triangular,
teardrop and boomerang configurations of their spinal cords. The tear drop type
was in 15 patients (50.00%), triangular type was in 10 patients (33.33%) and
boomerang type was in 5 patients (16.67%).
In this study, the recovery rate by Hirabayashi formula was ranged from 25-100%
with the mean 69.96±16.89%.
The recovery rate in single level corpectomy ranged from 50-100% (Mean 74.90%),
in two-levels corpectomies ranged from 25-85.71% (Mean 62.85%), while in three-levels
corpectomies (only one patient) 83.33%.
Signal hyperintensity T2-weighted changes of the spinal cord were correlated
with the more severe neurological deficit (20 patients 66.66%). The pre-op Bm
JOA of those patients were the worst (4/18-11/18).
Operative finding: All patients (30 patients, 100%) were operated by
ACCF and plating. All patients were operated in supine position with mild neck
extension. The duration of surgery ranged from 110-210 min with the mean 157±27.62
min The volume of intraoperative blood loss ranged from 400-1100 cc with mean
of 530 cc. Eighteen 1 patients (60%) needed intraoperative transfusion of 1
unit of blood and 3 patients (10%) need Intraoperative transfusion of 2 units
of blood.
In this study, C4 was involved in the corpectomy/ies of 12 patients (49%),
C5 was involved in the corpectomy/ies of 19 patients (63.3%) and while C6 was
involved in the corpectomy/ies of 14 patients (46.7%). The average number of
vertebral bodies involved is 1.5. One level corpectomy was done in 16 patients
(53.33%), 2 level-corpectomies in 13 patients (43.33%) and only in one patient
(3.33%) 3 level corpectomies was done.
Nurick classification was done preoperative and six months later. The best
preoperative Nurick grade was 2 and the worst was 5 (mean 2.33), while the best
post-operative Nurick grade was 0 and the worst was 4 (Mean 0.73). The best
improvement was 3 degrees and the worst was one degree improvement. There were
no patient with deterioration in Nurick grading (mean degree of improvement
is 2.5 grade up).
Difference in improvement in Bm JOA in continuous, segmental and mixed types
of OPLL was insignificant p value of 0.70. Improvement in Nurick grading in
this study ranged from 0-100% with mean of -76.83±25.44%.
Improvement in Nurick grading difference between continuous, segmental and
mixed types of OPLL was insignificant p-value of 0.666.
Postoperative complications: Postoperative complications occurred in
7 patients (23.33%). And includes temporary dysphagia in 5 patients (16.66%)
and disappeared in 2-5 days post-operative, motor weakness in 2 patients (6.66),
donor site infections in 4 patients (66.6%) (Table 3).
Pre and post-operative cervical regional and Cobb angle in neutral position
were measured. Pre-op Regional cervical angle ranged from 2-20 degrees (Mean
7.70±4.53) while post-op Regional cervical angle ranged from 7-25 degrees
(Mean 13.63±4.85). Pre-op Cobb’s angle ranged from 3-18 degrees
(mean 9.63±3.66), while the post-op Cobb’s angle ranged from 1-25
degrees (Mean 16.20±5.31).
| Table 3: |
Incidence of complications in the current study |
 |
Radiological follow up included plain X-ray, CT and magnetic resonance image:
Plain X-rays follow up were accepted in all patients except for one patient
after 2 months which showed pulled out screws and plate was elevated from the
body of the vertebra above (C3). The recovery rate for him was 25% after the
primary surgery and still the same (25%) after the second operation.
CT was done after 6 months to all patients. The decompression was evident in
all patients with successful bony fusion. MRI was done in the 6 months follow
up period and demonstrated a regression or stationary in the postoperative expansion
of the high signal intensity area of the spinal cord.
In this study, there was a positive correlation between the postoperative high
signal intensity area of the cord and neurologic outcome. A decrease in the
extent of expansion of the high signal intensity area was found in 25 patients
(83.33%) with recovery outcome rate ranged from 60-100%. It was stationary in
5 patients (16.67%) with recovery outcome rate ranged from 25-50% (Mean 40.18%).
Neurological improvement rates in anterior approaches to cervical OPLL are
summarized in (Table 4). Improvement rates varied from 51-71.7%.
There are many varieties of techniques, bone grafts and instrumentations for
anterior approach surgery.
The most common presenting complaint of the patients were paresthesia or numbness
of the hands, sphincteric dysfunction and difficulty in walking that were found
in all patients (100%).
The most common presenting sign was hyperthesia, gait disturbance and weakness
which found in 30 patients (100%) followed by hyperreflexia that was found in
29 patients (96.66%).
| Table 4: |
Summary of outcomes for anterior approach surgery in cervical
OPLL |
 |
|
|
| Fig. 1(a-e): |
Plain x-ray cervical spine antropesterior and lateral view
demonstrated spondylotic changes with multiple ostephyte formation and narrowed
(a) C 5-6, C6-7 spaces, (b) CT scan demonstrating segmental type of OPPL
opposite C5 and C6 (c) MRI sagittal T2 WI and axial T2 WI shows large diffuse
posterior prolapsed C5-6 markedly compressed cord and both related nerve
roots (d) post-operative plain x ray AP and lateral view with internal fixation
by plate from C4 to C7 and (e) post operative MRI axial and saggital T2
WI after 6 months shows decompressed cord and widening of the neural canal |
Pre-operative radiological studies
Pre-operative radiological images: This is a male patient 50 years old
was found to have cervical spondylotic myelopathy and OPLL Fig.
1a: Plain X-ray cervical spine A-P, lateral demonstrating spondylotic changes
with multiple osteophytes formation and narrowed C5-6 and C6-7 spaces.
DISCUSSION
Cord compression involves both of the mid-vertebral as well as to the vertebral
endplate levels. Therefore, anterior discectomy performed through the disc spaces
fails to yield a good decompression and subsequently outcome (Mizuno
and Nakagawa, 2001).
In this study, there were 19 males (63.33%) and 11 females (36.66%) with female
to male ratio 1:1.73 In accordance with this current study, Maeda
et al. (2001) and Kaneko (2006) found a female/male
ratio of 1:2. Wu et al. (2011) found that about
2-fold higher risk of OPLL in men more than in women with incidence female to
male ratio 1:2.65.
In this study, the age of the patients ranged from 35-65 years (Mean 48.93±7.89
years). Taketomi (1997) found that the age of symptomatic
patients ranged from 27-78 years (Mean 54.5 years). In the study of Kaneko
2006, the average age at the onset of symptoms was about 50 years, While
in Saetia et al. (2011), it was in the 5-6th decade
of life. Wu et al. (2011), found that the incidence
of myelopathy with OPLL increased by a rate of 80% for every 10-year increase
in age.
Epstein (2002) found that the segmental types occurs
in most cases (39%), In Tanaka et al. (2006) reported
that the segmental type is the most common (39%). Rhee
et al. (2009) and Nagata and Sato (2006),
found the same that segmental type was 39% of patients with cervical OPLL. The
continuous, mixed and localized types occurred in 27, 29 and 7%, respectively.
While in Kalb et al. (2011) found that the segmental
type occurs in most cases also (36.4%) followed by localized types (27.3%),
the mixed (21.1%), continuous (15.2%).
In this study, C4 was involved in 12 patients (49%), C5 was involved in 19
patients (63.3%), while C6 was involved in 14 patients (46.7%). The average
number of vertebral bodies involved is 1.5. This number is less than other series
as (Nagata and Sato, 2006). This may be due to
the small number of the sample in this study or due to the extensive disease
in Japanese people than Egyptians but this need more epidemiological studies
for further explanation. They detected cervical OPLL (in order of frequency)
at levels C4 (68%), C5 (49%) and C6 (44%). The average number of vertebral bodies
involved is 3.1 (Nagata and Sato 2006). Involvement of
two levels was the most common and always included C5 and C6. The most affected
levels by both disc herniation and spondylosis are C6-C7disc, followed by C5-C6
disc (Shedid and Benzel, 2007).
Dalbayrak et al. (2010) found that the mean
JOA score was 13.44 and Ozer et al. (2009),
it was 12.7. These figures were near the mean of the current study. In this
study pre-op Bm JOA scores were ranged from 4-17 (Mean 11.43±2.56) In
continuous type of OPLL, pre-op Bm JOA scores were ranged from 8-15 (Mean 11.57±2.44).
In segmental type, they were ranged from 9-17 (Mean 14.14±2.41). In mixed
type they were ranged from 4-14 with the mean 11.06±2.74. Pre-op Bm JOA
scores difference between continuous, segmental and localized types of OPLL
was insignificant p value of 0.654.
Pre-op Bm JOA scores difference between boomerang, teardrop and triangular
types of OPLL was insignificant p value of 0.988. Rajshekhar
and Kumar, (2005), found that Nurick Grade ranged from 4-5, with the mean
4.11.Agrawal et al. (2004), demonstrated the
Nurick Grade ranged from 3-5 with the mean 3.34. In this study, pre-op Nurick
grading was ranged from 2-5 with the mean 3.23±0.68. Pre-op Nurick grading
difference between continuous, segmental and mixed types of OPLL was insignificant
(p-value of 0.454) and this is in accordance with (Rajshekhar
and Kumar, 2005) and also with Agrawal et al.
(2004).
The duration of symptoms in the studied patients ranged from 3-36 months (Mean
12±10.11 months). In accordance with Hoh et al.
(2011), the patients of this study presented by axial pain (neck pain),
followed by tightness of the trunk or legs and lastly sphincteric dysfunctions,
difficulty of walking and weakness. The axial discomfort may originate from
stimulation of the sinuvertebral nerve spreading in the posterior longitudinal
ligament or constriction of the nerve root in the canal; however, the exact
origin remains unclear (Kaneko, 2006).
The most common presenting complaint of the patients were paresthesia or numbness
of the hands, sphincters dysfunction and difficulty in walking that were found
in all patients (100%). Motor dysfunction was also present on all patients.
The second most common complaint was clumsiness of the fingers that was found
in 27 patients (90%). Other clinical manifestation were axial pain (neck pain
in 26 patients (86.66%), quadriparesis (83.33%), stiff spine in 18 patients
(60%), tightness of the trunk or legs in 16 patients (53.33%), upper limb weakness
only (16.67%). The incidence of symptoms and signs did not gain statistical
value. Kaneko (2006) found that the symptoms were neck
pain in 69% of patients, numbness of the upper limbs in 67%, motor weakness/clumsiness
of the upper limbs in 42%. The incidence of symptoms in this study was higher
than that of Kaneko. This may be explained by the late presentation of the patients
to seek the proper medical advice.
As regard to myelopathy, the comparison with others is of a little value because
myelopathy must be present in all the studied patients as an inclusion criterion.
Others had different inclusion criteria, so Matsunaga et
al. (2004), reported that only about 40% of OPLL symptomatic patients
presented with myelopathy compared to 20-50% in the study of Epstein
(1997).
According to Tsuyama (1984), no specific symptoms
and signs of cervical OPLL are reported. Approximate 45% of patients with cervical
OPLL have some neurological symptoms, About 45% of patients with OPLL have motor
dysfunction of the extremities and 16.8% of patients need help with their activities
of daily living; 5% of patients have no symptoms (Tsuyama,
1984). Another nationwide survey in Japan done by Terayama,
1976 reported that pain/numbness of the upper limb was 74%, neck pain was
64%, changes of reflexes in the lower limbs were 58%, sensory chanes in the
upper limbs were 55% and changes of reflexes were the upper limbs 52%.
The most common presenting sign of the patients was hyperthesia, gait disturbance
and weakness that were found in all patients. The second most common sign was
hyperreflexia that was found in 29 patients (96.66%).
Rhee et al. (2009) stated that the manifestations
of cord signal changes or myelomalacia are significant in diagnosis, especially
Hoffman, clonus, hyperreflexia of the biceps, triceps and brachioradialis.
No significant differences are present in the prevalence of Inverted Brachioradialis
Reflex (IBR), Babinski, or patellar and Achilles reflexes.
Kaneko (2006) found that changes in reflexes (biceps
and triceps tendon reflexes) existed in 59% (hyperreflexia 52%, hyporeflexia
7%), positive Hoffman’s reflex in 41% and sensory change in 56%. Those
in the lower limbs were hyperreflexia of the patellar or ankle tendon reflexes
(or both) in 57%, positive Babinski’s reflex in 25% and sensory changes
in 37%. There was a distinct difference in the laterality in 27% of patients.
Plain radiography is the simplest method for detecting OPLL but it has some
limitations. Chang et al. (2010) reported low
inter and intra observer reliability of lateral radiography, as a tool for OPLL
classifications. They emphasized the importance of CT with 3D reconstructed
images to overcome this problem. This was in agreement with the current study
as CT was used as a crucial tool for diagnosis. Evaluation of regional cervical
angle and Cobb’s angle was done using both X-rays and mid sagittal CT.
Computed tomography and/or myelography are useful tools for detecting and accurately
locating OPLL (Saetia et al., 2011). In Mizuno
and Nakagawa (2001) retrospectively found that bone window CT scans were
the most useful method for detecting dural ossification, whereas MR imaging
was ineffective in recognizing dural ossification. Computed Tomography (CT)
is exquisitely sensitive to ligamentous ossification and calcification and it
represents a “gold standard” in the diagnosis of OPLL.
These considerations about X-ray and CT in diagnosis of patients in the current
study were in accordance with Mizuno et al., (2005),
Tanaka et al., (2006), Saetia
et al., (2011).
By using the axial MRI and CT, in this study, OPLL was categorized into 3 types;
triangular, teardrop and boomerang configurations as used by Matsuyama
et al. (2004). The tear drop type was detected in 15 patients (50.00%),
triangular type was in 10 patients (33.33%) and boomerang type was in 5 patients
(16.67%). In Matsuyama et al., 2004 found out
tear drop type in 13 patients (29.54%), triangular type in 10 patients (22.73%)
boomerang type in 21 patients (47.73%).
MRI was done in the current study to assess the associated disc prolapse and
cord signal changes but it was less sensitive for ossification and calcification.
This is in accordance with Tanaka et al. (2006)
who found that MRI is less sensitive and less specific for the diagnosis of
a small ossified or calcified mass. Its principal use is in the assessment of
associated cord compression and intramedullary cord lesions such as cord edema
and myelomalacia.
In MRI of the current studied patients, a characteristic OPLL, signal hypointensity
on both T1 and T2-weighted MR imaging were found in all patients. MR imaging
was helpful for determining the actual level of spinal cord compression and
for suggesting the optimal method of surgical treatment. Signal hyperintensity
T2-weighted changes of the spinal cord were correlated with more severe neurological
deficit (20 patients 66.66%).The pre-op Bm JOA of those patients were the worst
(4/18-11/18). This was in accordance of the studies of Koyanagi
et al. (1998) and Saetia et al. (2011).
In this study ACCF associated with anterior cervical fixation system were done
with removal of the OPLL in most cases (83.33%), however in 5 cases the ossified
ligaments were adherent to the dura, so floating method of freeing the edges
of the ligament were done to avoid the risk of dural tear, cord injury or CSF
leakage. All the five cases were of continuous type of OPLL. Three of them were
boomerang type and two were of triangular type. So it is recommended to take
more care during resection of the continuous type of OPLL. One level corpectomy
was done in 16 patients (53.33%), 2 levels corpectomies in 13 patients (43.33%)
and only in one patient (3.33%) 3 levels corpectomies was done.
A high degree of localized, continuous, or mixed type narrowing, where the
results of posterior decompression are questionable, constitutes an absolute
indication for anterior decompression, preferably by the anterior floating method.
The floating method of removal of OPLL described by Yamaura
et al. (1999). It involves thinning and releasing the ossification,
which results in massive anterior floatation. Transverse decompression includes
the lateral bony protuberance and generally extends more than side to side 20
mm to avoid residual ossification to prevent insufficient floating of the ossification
(Shinomiya et al., 2006).
In this study, the recovery rate by Hirabayashi formula was ranged from 25%
to 100% (mean 69.96±16.89%).This was in accordance with many studies
done from 2006-2010; (Nakase et al., 2006) found
that mean improvement rate was 67.4% (12 patients), while in Iwasaki
et al. (2006) it was 51% (27 patients), in Chen
et al. (2009) it was 63.2% (19 patients), in Kim
et al. (2009) it was 71.7% (17 patients) and in Dalbayrak
et al. (2010) it was 59.65% (29 patients).
In this study the difference in improvement in Bm JOA in continuous, segmental
and mixed types of OPLL was insignificant (p value = 0.70). In continuous type
of OPLL, the mean of improvement in Bm JOA was 40.72±23.32%. In segmental
type, the mean of improvement was 40.24±22.52%. In mixed type, the improvement
was 96.69±2.41%.
The recovery rate difference between boomerang, teardrop and triangular types
of OPLL was insignificant (p-value = 0.458). In contrast to the study of Matsuyama
et al. (2004), they found that the recovery rate were the worst for
those with triangular (23%), intermediate for those with boomerang (61.8%) and
the best for those with teardrop shapes (72.1%). This is may be due to the difference
in percentage of each type between their study and the current study, especially
in boomerang type which was found in 5/30 patients only in comparison to 21/44
in Matsuyama et al. (2004).
In this study, post op Nurick grading were ranged from 4 to 0 with (Mean 0.83±0.99).
Improvement in Nurick grading in this study ranged from 0 to -100.00% (mean
= 76.83±25.44%). Improvement in Nurick grading difference between continuous,
segmental and mixed types of OPLL was insignificant (p-value of 0.666).
Improvement in Nurick grading difference between boomerang, teardrop and triangular
types of OPLL was insignificant (p-value of 0.604). In the current study radiological
follow up demonstrated that plain X-ray that used especially in the early post-op
period, to evaluate the bone graft and the anterior fixation system was accepted
in all patients except for one patient (3.3%). After 2 weeks of surgery and
during an epileptic fit (known epileptic taking AEDs), screws were pulled out
and plate was elevated from the body of the vertebra above (C3) and the patient
had been reoperated again. The first operation was ACCF, corpectomies of C4
and C5, iliac bone graft and fixation 2 screws in both C3 and C6 with one screw
in the graft.It showed pulled out screws and the plate had been elevated from
the body of the vertebra above (C3). The recovery rate for him was 25% after
the primary surgery and still the same (25%) after the second operation.
CT done 6 months for all patients showed adequate decompression evident in
all patients with successful bony fusion.
MRI was done in the 6 months follow up period and demonstrated a regression
or stationary in the postoperative expansion of the high signal intensity area
of the spinal cord. A decrease in the extent of expansion of the high signal
intensity area was found in 25 patients (83.33%) with recovery outcome rate
ranged from 60-100% (mean 75.53%). It was stationary in 5 patients (16.67%)
with recovery outcome rate ranged from 25-50% (mean 40.18%).
The same correlation was also reported by Yagi et al.
(2010) who demonstrated a positive correlation between postoperative expansion
of the high signal intensity area of the spinal cord and poor neurological outcomes
of patients with cervical OPLL.
In the anterior median cervical corpectomy, it has been reported an overall
complications of 24% including cerebrospinal fluid leakage, motor power deterioration,
cervical wound or donor site infections and pseudarthrosis with or without dislodgement
the grafted bone. Salvage operation was required was 12.5% (Toyama
et al., 1997).
The overall complications were detected in 23.33% in this series. Motor power
deterioration had occurred in 2 patients (12.5%, insignificant p value: 0.39).
Both of them had mixed type of OPLL, one had boomerang type (20%) while the
other patient had a triangular type (10%) (insignificant p-value: 0.262). There
was only one patient (6.2%) with cervical wound infection.
Temporary dysphagia was reported in five patients in this study relieved after
2-4 days. Oral feeding was not interrupted and no need for nasogastric tube
feeding. Hot drinks only were used with no specific medications. Temporary dysphagia
occurred in 16.7% of the patients, one in the single corpectomy group = 6.2%
(insignificant p value: 0.036), three in double corpectomies group = 23.1% (insignificant
p-value: 0.064) and one in the triple corpectomy patient = 100% (insignificant
p-value: 1).
Fortunately, there was no case complicated by CSF leakage in this study; however,
in Mizuno and Nakagawa (2001) reported a 20% incidence
of CSF leak. Cervical dural tears and CSF leaks after anterior decompression
procedures has ranged from 0.5-3%. For OPLL (including the floating method also)
it was much higher, ranging from 4.3-32% (Mazur et al.,
2011).The incidence in the study of Cardoso et al.
(2011) was between 6.7 and 31.8%. It increased from 5.6 and 5.3% for a 1
and 2-level corpectomy, respectively, to 16.7% for a 3-level corpectomy (Cardoso
et al., 2011).
CONCLUSION
Anterior corpectomy with resection or floating of the ossified mass followed
by fusion is a radical surgical procedure best indicated for cervical spondylotic
myelopathy with OPLL that extends fewer than three vertebral levels below C-3
and above C-7 in a patient with no congenital stenosis or cervical spine trauma.
