Abstract: Due to high content of phenolic compounds that exhibit pharmacological activities such as antioxidant, the leaves of artichoke have important drug values. In present experiment, the effect of salt stress on phenolic compounds and antioxidant activity of artichoke leaves grown up in the field and pot conditions were studied. The salinity of the soil varied from 1.5 to 20.6 dS m-1 and 1.3 to 29 dS m-1 in pot and field experiments, respectively. Results showed that the highest amount of these compounds was recorded at 6.9 and 6.45 dS m-1 in pot and field experiments, respectively. As salinity increased up to 6 in both experiment, a reduction in total phenol and flavonoid was observed. Results showed that the antioxidant activity of leaf, positively increased by the salinity levels; in both trials the maximum antioxidant activity (IC50 = 0.01 mg mL-1) was observed at highest level of salinity. Similar to phenolic and flavonoid compounds the contents of chlorogenic and caffeic acids were at their highest levels in moderate salinity. Caffeic and chlorogenic acids accumulation was limited by high level of salinity without reduction in antioxidant activity. It can be concluded that at under the moderate and high salinity conditions, health-promoting compounds (polyphenol contents) in artichoke leaves are enhanced.