Abstract: Use of plants for health benefits is widespread in India. The present study was to investigate ethanolic seed extract of Caesalpinia crista for antioxidant activity by 1,1-diphenyl-2-picryl hydrazyl and hydrogen peroxide methods and anti inflammatory by Carrageenan induced paw edema and analgesic activity by writhing reflexes and by tail immersion method in mice. The extract showed potent antioxidant activity i.e., 73.9 and 77.7% at 300 μg mL-1 by 1,1-diphenyl-2-picryl hydrazyl and hydrogen peroxide method as compared to the standard (ascorbic acid). Further, the extract was evaluated for anti inflammatory activity and the extract showed maximum inhibition of 74.2% at 300 mg kg-1 by Carrageenan induced paw edema method as compared to standard (diclofenac). Furthermore, the extract was evaluated for analgesic activity the extract showed potent analgesic activity i.e., 71% at 300 μg mL-1 by writhing reflexes in mice and the tail withdrawal latency of mice was 5.30±0.05 sec at 300 μg mL-1 by tail immersion method. The present study concludes that Caesalpinia crista seeds have potent antioxidant, anti inflammatory and analgesic activity it can be used for therapeutic potential.