
	Research Journal of Phytochemistry
	Year: 2012 \| Volume: 6 \| Issue: 4 \| Page No.: 127-131 DOI: 10.3923/rjphyto.2012.127.131

Phytochemical Investigation and Cytotoxic Properties of Tabernaemontana catharinensis A. DC. Cultivated in Brazil

A.A. Boligon and M.L. Athayde

Abstract: Many laboratories of natural products have entered into their routines various biological assays simple and phytochemical study of plants extracts used popularly in medicine in order to select bioactive substances. Tabernaemontana catharinensis is a medicinal plant used in folk medicine with antidote for snakebites, to relieve toothache and as a vermifuge to eliminate warts. Phytochemical constituents and cytotoxic effect of the plant were investigated using the qualitative analysis and the brine shrimp lethality method, respectively. The phytochemistry of aqueous and hydroalcoholic extracts of T. catharinensis leaves and stem bark revealed the presence of alkaloids, flavonoids, phenols, tannins, sterols, saponins, catechins and coumarins. The aqueous extracts of this plant did not induce the lethality in the brine shrimp (Artemia salina Leach) bioassay (LC₅₀= 1057.90±0.48 and 1002.5±0.36 μg mL^-1 for leaves and stem bark, respectively); however, hydroalcoholic extracts shows cytotoxicity for this crustacean (LC₅₀ = 629.35±0.12 and 504.18±0.15 μg mL^-1 for leaves and stem bark, respectively). In this study, it was observed that the toxicity to Artemia salina converged to the extracts containing the highest amount of bioactive compounds (hydroalcoholic extracts), other in vivo tests will be conducted to determine the exact mechanism of action involved in the toxicity described.

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How to cite this article:

A.A. Boligon and M.L. Athayde, 2012. Phytochemical Investigation and Cytotoxic Properties of Tabernaemontana catharinensis A. DC. Cultivated in Brazil. Research Journal of Phytochemistry, 6: 127-131.

DOI: 10.3923/rjphyto.2012.127.131

URL: https://scialert.net/abstract/?doi=rjphyto.2012.127.131

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