Abstract: The phytochemical analysis on stems of Stachytarpheta jamaicensis proved the presence of secondary metabolites, including; tannins, saponins and flavonoids Crude concentrations of aqueous extract of stem showed antimicrobial activity on Bacillus subtilis, Escherichia coli, Candida albicans, Staphylococcus aureus, Pseudomonas aureginosa and slight activity on Proteus vulgaris while the alcoholic extract had almost similar activity, but lesser activity was observed on Escherichia coli.