Abstract: The effects of T. occidentalis on serum lipid profile, non-HDL cholesterol and atherogenic indices were investigated in male wistar rats. The rats were fed for 28 days on diet formulated to contain 12.5, 37.5 and 75 g by weight of T. occidentalis seeds while the control group was fed on standard rat diet. Total cholesterol, Triglyceride, LDL, HDL and VLDL cholesterol were determined on blood samples collected on the 28th day using standard methods while atherogenic indices and non-HDL cholesterol were calculated using internationally accepted formula. The supplemented diet led to significant decrease in serum total, LDL, VLDL and Non-HDL cholesterol relative to control (p<0.05) while inducing a significant increase in HDL cholesterol though the effect appeared more pronounced at 37.5 g/weight. The diet supplementation also led to significant decrease in CRR, AC and AIP (p<0.05). These results suggest a possible dose dependent protective role of T. occidentalis seed against development of cardiovascular disease and in the management of dyslipidaemic conditions.