Abstract: Cirrhosis is one of the most degenerative, world wide diseases and can be lead to an inability of liver functions. Green Tea (GT) and Coffee are natural products and considered as powerful antioxidant, chemoprotective, antiinflammatory and antitumorigenic agent. The present study was designed to investigate the protective effect of green tea and coffee against Carbon tetrachloride (CCl4)-induced liver cirrhosis by using biochemical and histopathological parameters. 24 Male Albino Wistar rats were randomly divided into 6 groups; each group consists of 4 rats. Group I comprises normal healthy rats remains untreated; Group II comprises of CCl4 (0.8 mg/kg) induced Cirrhotic rats; Group III was administered coffee orally (1 gm/100 mL) daily; Group IV administered CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 1% oral administration of coffee; Group V was administered 5% Green tea orally; Group VI comprises of CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 5% oral administration of Green Tea. The volume of green tea and coffee ingested by rats of group III and V was measured daily. The effect of antioxidants on CCl4-induced liver cirrhosis were estimated by plasma ALT, ALP, total and direct bilirubin, tissue MDA, tissue SOD, tissue catalase. CCl4-induced cirrhosis is indicated by increased level of plasma ALT, direct bilirubin, tissue MDA and decreased level of tissue SOD. Pathological changes induced by CCl4 were characterized by fibrotic scar tissue as well as regenerative nodules, the parenchyma deteriorates; the lobules are infiltrated with fat and structurally altered; dense perilobular connective tissue. Coffee and green tea reduced these changes and also restored antioxidant and liver enzymes. Our results showed the possible protective effect of coffee and green tea in association with liver and antioxidant enzymes, indicated that administration of coffee and green tea not only reversed the pathological effects of CCl4 but also counteracted on deleterious effects of CCl4- induced liver injury.