Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
American Journal of Drug Discovery and Development
  Year: 2011 | Volume: 1 | Issue: 4 | Page No.: 209-219
DOI: 10.3923/ajdd.2011.209.219
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Normalisation of Lipoprotein Phenotypes by Chromolaena odorata-Linn. in Carbon Tetrachloride Hepatotoxicity-Induced Dyslipidaemia

C.S. Alisi, A.O. Ojiako, G.O.C. Onyeze and G.C. Osuagwu

Abstract:
The major functions of the liver can be detrimentally altered by liver injury resulting from acute or chronic exposure to toxicants. Dyslipidemia is often found in such toxicity resulting from chemical damage. Normalisation of atherogenic indices by Chromolaena odorata (C. odorata ) in carbon tetrachloride-induced liver toxicity was evaluated in 30 male rabbits divided into 5 groups of 6 animals each. Normal Control (NC) received food and water only. Carbon tetrachloride intoxicated control (CCl4) received a single dose of CCl4 (0.2 mL kgbw-1 in liquid paraffin 1:1). C. odorata test animals (ETECO TEST) received a single dose of CCl4 + ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1 morning and night, for 6 days. C. odorata control animals (ETECO CTRL) received ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1. Group five (Sylimarin) received sylimarin 50 mg/kgbw prior to CCl4 intoxication. Carbon tetrachloride-induced toxicity resulted in liver injury which was seen from the significant (p<0.05) elevation of the activities of serum Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Lactate Dehydrogenase (LDH) and gamma-Glutamyl Transferase (γ-GT), significantly decreased protein and albumin and significantly increased total bilirubin concentrations; altered lipid and lipoprotein phenotypes in favour of increased atherogenic indices. Pre-treatment with C. odorata extract prevented these biochemical alterations and normalized the lipoprotein phenotypes. C. odorata may be useful not only as a hepatoprotective agent, but also in the reduction and/or prevention of adverse cardiovascular events.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Estimating the Plasma and Serum Activity Levels of Aspartate Aminotransferase and Alanine Aminotransferase, in Live Animals Using Regression Model
  •    Soy Diet Diminish Oxidative Injure and Early Promotional Events Induced by CCl4 in Rat Liver
  •    Methanolic Root Extract of Olax viridis Protects the Liver against Acetaminophen-induced Liver Damage
  •    Effects of the Extracts of Pycanthus angolensis Against Chemically Induced Acute Hepatotoxicity
  •    Acute Toxicity and Hepatoprotective Effect of Methanolic Extract of Tephrosia calophylla
  •    Evaluation of the Hepatoprotective Effect of Fumaria parviflora and Momordica balsamina from Saudi Folk Medicine Against Experimentally Induced Liver Injury in Rats
  •    Hepatoprotective and Antioxidant Activity of Root Bark of Calotropis procera R.Br (Asclepediaceae)
How to cite this article:

C.S. Alisi, A.O. Ojiako, G.O.C. Onyeze and G.C. Osuagwu, 2011. Normalisation of Lipoprotein Phenotypes by Chromolaena odorata-Linn. in Carbon Tetrachloride Hepatotoxicity-Induced Dyslipidaemia. American Journal of Drug Discovery and Development, 1: 209-219.

DOI: 10.3923/ajdd.2011.209.219

URL: https://scialert.net/abstract/?doi=ajdd.2011.209.219

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom