Abstract: Three homogentisic acid derivatives, namely methyl 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetate (1), 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetic acid (2), methyl 2-(1`β-geranyl-5`β-hydroxy-4`β-methoxy-2`-oxocyclohexyl)acetate (3), isolated from the leaves of Glossocalyx brevipes, were screened for antisalmonellal activity using both agar diffusion and broth dilution techniques. Only compound 2 showed significant antimicrobial activity against Salmonella typhi (26 mm), Salmonella paratyphi A (23 mm) and Salmonella paratyphi B (22 mm). The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were 10 and 80 μg mL-1, respectively, against all the three bacteria strains used. These data support the use of Glossocalyx brevipes in anti-typhoid preparations.