Submit Manuscript

International Journal of Pharmacology

Year: 2010 | Volume: 6 | Issue: 3 | Page No.: 173-182
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 893

Search

Authors

Donatien Gatsing

Christiane F.N. Nkeugouapi

Bridget F. Nji-Nkah

Jules-Roger Kuiate

Felicite M. Tchouanguep

Keywords

The antibacterial activity, bioavailability and acute toxicity of the leaf extracts of Alchornea cordifolia were evaluated. The phytochemical screening was also done. Results of the in vitro antibacterial tests showed that all but the hexane extract exhibited antibacterial activities against P. aeruginosa (MIC = 2.5 mg mL-1), E. coli (MIC = 3.75 mg mL-1), S. aureus (MIC = 5 mg mL-1) and K. pneumoniae (MIC = 10 mg mL-1). Results of the serum antimicrobial activity test against P. aeruginosa showed that with animals administered the extract, serum antimicrobial activity was observed as from 3 h 45 min for the doses 2.84 and 5.68 g kg-1, independently of the sex of animals. The peaks of serum activity (maximum activity, Amax) were obtained at 6 and 4 h (Tmax) with the doses 2.84 and 5.68 g kg-1, respectively. The area under the curve (AUC) was greater with the dose 2.84 g kg-1 than with the dose 5.68 g kg-1. Flavonoids, triterpenes, saponins, anthocyanins, steroids, polyphenols and tannins were found in the leaves of this plant. Results of the acute toxicity study of the aqueous leaf extract of A. cordifolia with mice showed that the LD50 was >32 g kg-1. The data obtained in this study suggest that the leaves of A. cordifolia contain antibacterial principle(s) which are biologically available and which may not be toxic. However, at doses ≥4 g kg-1, this extract may have a depressant or sedative effect on the central nervous system, may reduce the pain perception and may induce loss of body weight.
PDF Fulltext XML References Citation

How to cite this article

Donatien Gatsing, Christiane F.N. Nkeugouapi, Bridget F. Nji-Nkah, Jules-Roger Kuiate and Felicite M. Tchouanguep, 2010. Antibacterial Activity, Bioavailability and Acute Toxicity Evaluation of the Leaf Extract of Alchornea cordifolia (Euphorbiaceae). International Journal of Pharmacology, 6: 173-182.

DOI: 10.3923/ijp.2010.173.182

URL: https://scialert.net/abstract/?doi=ijp.2010.173.182

Related Articles

Effect of the Aqueous Extracts of Alstonia boonei on the Haematological Profiles of Mice Experimentally Infected with the Chloroquine-Sensitive Strain of Plasmodium berghei NK-65
A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing
Antidermatophytic Activity and Dermal Toxicity of Essential Oil from the Leaves of Ageratum houstonianum (Asteraceae)
Antimicrobial Activity Evaluation of Cassia spectabilis Leaf Extracts
International Journal of Pharmacology 2010: A Tremendous Year and Future Prospects
Antisalmonellal Activity and Phytochemical Screening of the Various Parts of Cassia petersiana Bolle (Caesalpiniaceae)
An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae)

Leave a Comment

Your email address will not be published. Required fields are marked *