Abstract: Heavy metals significantly inhibited ascospores germination, differentiation and ascus formation in Dipodascopsis uninucleata. Sliver nitrate was the most inhibitory one even at low concentration (50 ppm). Among the tested zinc salts, zinc acetate was the most effective in inhibiting growth activities. Two phenomena have been observed in the present investigation. At concentration 600 ppm of manganese nitrate, D. uninucleata grow in the form of spherical pellicles with imperfect stage of reproduction represented by conidial heads similar to that of aspergilli. High concentration (1000 ppm), produced the yeast phase of D. uinucleata.