Abstract: Medicinal plants have been traditionally used for the treatment and prevention of peptic ulcer. The present study was designed to investigate antioxidant and antiulcer potential of methanolic fruit extract of Prunus domestica. Antioxidant activity was measured by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide free radical scavenging method. The extract showed maximum scavenging activity i.e., 82.12±0.654 and 79.43±0.876 at 200 μg mL-1. Further the extract was evaluated for its anti-ulcerogenic activity by pyloric ligation model. The extract showed significant inhibition of ulcer i.e., 70.58% at 200 mg kg-1. The present study concludes that Prunus domestica fruit posses potent antioxidant and anti-ulcerogenic effect.