Abstract: The antioxidant property of Sida acuta was recently demonstrated, in vitro. We proposed that this property could confer some protective benefit in alloxan model of diabetes mellitus in rats and compared the efficacy of the methanolic and ethanolic leaf extracts of the plant in this study. Diabetes was induced with alloxan monohydrate (150 mg kg-1, intraperitoneally). Diabetic rats were divided into six groups of 7 rats/group and treated with either ethanolic extract of Sida acuta (EESA), methanolic extract of Sida acuta (MESA, 200 and 400 mg kg-1) or glibenclamide (200 mg kg-1) orally for three days. Diabetic and normoglycaemic control received normal saline (10 mL kg-1). Animals were sacrificed by cervical dislocation 24 h after last administration. The EESA and MESA exhibited similar hypoglycaemic activity at 200 mg kg-1. The EESA (200 mg kg-1) significantly (p<0.01) lowered malondialdehyde and increased glutathione (GSH) and Uric Acid (UA) at 400 mg kg-1. The MESA increased GSH at both doses, produced mild decrease in malondialdehyde and increased UA at 200 mg kg-1 (p>0.05). Both extracts significantly reduced plasma total cholesterol (p<0.05) and triglyceride (p<0.001). The hypoglycaemic and hypolipidaemic effects of EESA and MESA were comparable to that of glibenclamide which did not affect antioxidant parameters. Both extracts significantly (p<0.05) raised haematocrit and Total White Blood Cell (TWBC). The MESA produced significant (p<0.05) increases in TWBC while EESA (400 mg kg-1) significantly (p<0.05) reversed the decrease in neutrophil count. Overall, EESA and MESA possess comparable hypoglycaemic and hypolipidaemic effects and show similar potential in attenuating alloxan-induced anaemic state with EESA exhibiting greater antioxidant activity.