Abstract: Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. Therapeutically interesting and important drugs can be developed from plant sources which are used in traditional systems of medicines. Indian traditional system of medicine is based on empirical knowledge of the observations and the experience over millennia and more than 5000 plants are used by different ethnic communities in India. The present communication constitutes a review on the medicinal properties and pharmacological actions of Cassia auriculata L. and Cissus quadrangularis Wall. used in Indian traditional medicine. These plants are known to contain various active principles of therapeutic value and to possess biological activity against a number of diseases.