Abstract: This study aims to evaluate the susceptibility of the hedgehog (Hemiechinus auritus) to Schistosoma mansoni under the experimental condition. The susceptibility of this animal to S. mansoni infection was compared to the hamster (Permissive host) infection with the same parasite. In this study, 24 male of both hedgehogs and hamsters were used. Half of animals were infected with 250 S. mansoni cercariae. Eight weeks post infection; animals were sacrificed to determine the total worm burden, total eggs count, granuloma volume. The results revealed that a fecal examination of the infected hedgehogs showed no eggs were detected in the feces. The average of hamster’s pre-patent period (the onset of patency) was 44.0±1.0 days. The average of S. mansoni worms recovered from hedgehogs was 31.0±10.0 worms, while the worm recovered from hamsters was 82.0±18.0. The granuloma volume measured from hedgehogs and the hamsters were 74.0±56.0 and 119.0±75.0, respectively. Marked reduction in the some biochemical parameters after the infection with S. mansoni was recorded in infected hedgehogs and hamsters. In conclusion, the hedgehogs showed non possibility for this animal to be a risk for schistosomiasis in the field.