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Research Journal of Parasitology
  Year: 2007 | Volume: 2 | Issue: 1 | Page No.: 63-67
DOI: 10.3923/jp.2007.63.67
 
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A Simple Process for the Experimental Induction of Resistance in Schistosoma mansoni to Antishistosomal Agents

P.M. Lar and J.P.O. Oyerinde

Abstract:
This study was carried out to identify the easiest process of inducing drug resistance in the parent generation of S. mansoni in mice after subjecting them to drug pressure. Adult albino mice were infected with S. mansoni cercariae and were given various subcurative doses of niridazole orally at 2 weeks, 4 weeks and 8 weeks (that is 14, 28 and 56 days) post-cercarial infection followed by the curative dose of niridazole for (250 mg kg-1 body weight for 5 days). We found that the adult worms (8 weeks old) were highly susceptible to niridazole treatment and did not survive the various subcurative treatment that was given. But when three consecutive courses of (100 mg kg-1 b.wt for 5 days) of niridazole was given to mice 14 and 28 days post cercarial infection, resistance (Tolerance) occurred with the recovery of 34.82 and 28.28% worms, respectively when curative treatment was given to mice. Mice with 2 week old infections were preferred and thus served as appropriate model for the induction of resistance to niridazole, while other antischistosomal agents may be tested using this method. The process was reproducible and has been valuable for experiments to study the biological characteristics of the drug resistant S. mansoni.
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How to cite this article:

P.M. Lar and J.P.O. Oyerinde , 2007. A Simple Process for the Experimental Induction of Resistance in Schistosoma mansoni to Antishistosomal Agents . Research Journal of Parasitology, 2: 63-67.

DOI: 10.3923/jp.2007.63.67

URL: https://scialert.net/abstract/?doi=jp.2007.63.67

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