Abstract: The aim of present study was to evaluate immunomodulatory potential of ethanolic extract of Asparagus racemosus Wild. and Chlorophytum arundinaceum Baker. in comparison to established immunosuppressant Cedrus deodara wood oil (100 mg kg-1 b.wt.) in mice. The assessment of immunomodulatory activity on specific and nonspecific immunity was studied by Delayed Type Hypersensitivity (DTH) and neutrophil adhesion test respectively. Through Neutrophil adhesion test maximum sensitivity was observed in in vivo extract of C. arundinaceum while percent inhibition was maximum in in vitro extract of A. racemosus. In vivo Chlorophytum arundinaceum extract at 300 mg kg-1 dose statistically significantly inhibit the adhesion of neutrophils to nylon fiber. However, in vivo A. racemosus at the dose of 300 mg kg-1 was found to significantly decreased rat paw edema as compared to control, in vivo C. arundinaceumand in vitro A. racemosus extract. The present study has shown the immunomodulatory activity of both plants by potentiating humoral as well as cellular immunity.