Abstract: To consider the association of serum leptin with dyslipidemia in hemodialysis patients. For maintenance hemodialysis patients levels of serum pre and post dialysis blood urea nitrogen, lipid profiles and serum Leptin were measured. For the adequacy of hemodialysis the urea reduction rate was calculated. A significant difference of serum leptin between males and females of diabetics with more values in female dialysis patients was seen. In total patients a near significant and inverse correlation of serum leptin with serum LDL was seen. In male hemodialysis group a significant positive correlation of serum leptin with duration of hemodialysis and with the ages of the patients were seen, in this group also a near significant positive correlation of serum leptin with serum triglyceride levels was seen too. In total patients there was a near significant positive correlation of serum leptin with serum cholesterol of patients who had a cholesterol levels of more than 100 mg dL-1. Present data supports the hypothesis that in patients on hemodialysis, the association of leptin with cholesterol and triglyceride levels could show the positive effects of leptin on nutrition in hemodialysis patients which is in contrast to normal population.