Abstract: This investigation deals with the effect of inhalation of the pyrethroid, tetramethrine, on the histochemical components of the liver of albino rats. This pyrethroid is obtained from local market and is used as an insecticide for cockroaches and ants. Animals were kept individually in closed cages and 1ml of the pyrethroid was sprayed into each cage for 5 minutes daily for 15 days. The results showed that pyrethroid inhalation induced a significant decrease in the carbohydrate inclusions, total proteins and RNA content in the liver cells of treated animals. The magnitude of these changes was time-dependent.