Abstract: Sixty five (65) meat and kidney samples that were belong to the same calf, from different sources were analyzed for antibiotic residues. Detection of residual antibiotics in calf meat and kidney were made by Bacillus subtilis disc assay method. Data showed that 1.53 % of the meat and kidney results were positive. The research indicated an urgency to advocate rational use of antibiotics in animals for safeguarding the human health and the enforcement of standards as important in protecting public health.