Abstract: This study aims to synthesis of silver nanoparticles using aqueous extract of Canthium comandelicum leaves and evaluates its antibacterial activity, as well as antioxidant activity. Characterizations of silver nano particles (AgNPs) were determined by using ultraviolet-visible (UV-Vis) spectrophotometry, Scanning Electron Microscopy (SEM) and X-ray diffraction. The ultraviolet and visible absorption spectroscopy results show a strong resonance centered on the surface of silver nanoparticles at 430 nm. SEM showed the formation of silver nanoparticles were polycrystalline with nano sized grains. X-ray diffraction analysis showed that the particles were crystalline in nature with face centered cubic structure of the bulk silver with the broad peaks at 38.16, 44.44 and 64.20. The bactericidal properties of the synthesized AgNPs were investigated using the agar cup plate method. The results conclude that silver nanoparticles have good antibacterial activity against different microorganisms such as Bacillus subtilis, E. coli and S. aureus. The synthezied AgNPs shows higher antioxidant activity found by DPPH assay. The synthesized silver nanoparticcles and the leaf extract the plants were found to exhibit antibacterial as well as antioxidant property.