Abstract: A commercial probiotic (Biogen®) was tested against a commercial mycotoxin binder (Myco-Ad®) for their effects on survival, growth, body composition and hematological picture of common carp (cyprinus carpio) fed a naturally contaminated aquafeed with aflatoxin and ochratoxin. A total number of 150 apparently healthy fingerlings common carp cyprinus carpio were divided into 5 triplicate groups. G-1 (control) received naturally ration found contaminated with aflatoxin (22 ppb) and ochratoxin (15 ppb). The other four groups supplemented with Biogen® at a rate of 0.2 and 0.4% (G-2 and G-3) and Myco-Ad® at a rate of 0.15 and 0.25% (G-4 and G-5). Results showed a significant reduction (p≤0.05) in aflatoxin recorded in aquafeeds of G-2 and G-3, while ochratoxin level showed a significant reduction in G-3. The four groups received Biogen® and Myco-Ad® showed a significant improve in the final weight, feed intake, FCR, survival rate, protein efficiency, body composition represented an increase in crude protein and reduction of ether extract and also improve hematological picture represented in erythrocyte counts, hematocrite and hemoglobin. It can be concluded that aflatoxin and ochratoxin contamination of fish diets can cause many drastic effects on performance parameters, feed utilization, hematological picture and body composition of common carp. Hence, there is always a demand for risk assessment regarding mycotoxins especially with the moving to plant protein sources in the aquafeeds. Commercial probiotic Biogen® at a level of 0.4 and 0.2% has a good improvement effect among common carp fed mycotoxin contaminated aquafeed, followed by the commercial mycotoxin binder Myco-Ad® at a level of 0.25 and 0.15%.