Abstract: The aim of this study was to determine the prevalence of metabolic syndrome and its individual components in diabetic patients in Ghana. This prospective study included 456 diabetic patients and was conducted at the Komfo Anokye Teaching Hospital in the Ashanti Region of Ghana from January 2006 to May 2007. Metabolic syndrome was defined according to the National Cholesterol Education Programme Adult Treatment Panel 3 diagnostic criteria. The prevalence of metabolic syndrome was 55.9% in the studied population. Low HDL cholesterol was the commonest component (47.4%) of metabolic syndrome, followed by hypertension (46.9%). Female diabetic patients had higher prevalence of metabolic syndrome and its components and individually carried more components than male diabetics. Future cardiovascular disease (CVD) prevention strategies in Ghana should not overlook metabolic disease risk factors.