Abstract: The oral delivery of hydrophobic drugs faces a major challenge because of the low aqueous solubility of such compounds. Approximately, 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system because of their low bioavailability. The availability of the drug for absorption can be enhanced by presentation of the drug as a solubilizer within a colloidal dispersion. Self-emulsifying Drug Delivery Systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. The principal characteristic of these systems is their ability to form fine oil-in-water (o/w) emulsions or microemulsions upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drugs, which display dissolution rate-limited absorption. SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of the recent advances in the study of SEDDS and improvement of pharmacokinetic parameters of bioactives through SEDDS.