Abstract: Contrary to the sufficient availability of hundreds of papers on how to report randomized clinical trials, less attention is paid on details in design of randomized clinical trials specially on setting the objectives and hypotheses. This study aimed to discuss some aspects of setting objectives and hypotheses in randomized clinical trials. Interactively referring to several examples in literature, this study have discussed different details of setting objectives and hypotheses in randomized clinical trials and provided recommendations on how to do it the best it can be.