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Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 15 | Page No.: 775-779
DOI: 10.3923/pjbs.2011.775.779
 
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The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extracts on Insulin Sensitivity and Some Inflammatory Indicators in Patients with Type 2 Diabetes: A Randomized Double-blind Control Trial

N. Namazi, A.T. Esfanjani, J. Heshmati and A. Bahrami

Abstract:
Type 2 diabetes is a metabolic disorder that is strongly associated with cardiovascular risk. Inflammation is a potential risk factor for cardiovascular disease. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on insulin sensitivity and some inflammatory indicators in type 2 diabetic patients were studied. A randomized double-blind clinical trial on 50 men and women with type 2 diabetes was done for 8 weeks. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into two groups, an intervention and control group. They received, 100 mg kg-1 nettle extract or placebo in three portions a day for 8 weeks. Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) , High Sensitive C-Reactive protein (hs-CRP) and Fasting Insulin concentration were measured. Insulin Sensitivity was calculated, at the beginning and the end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, IL-6 and hs-CRP showed a significant decrease in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has decreasing effects on IL-6 and hs-CRP in patients with type 2 diabetes after eight weeks intervention.
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How to cite this article:

N. Namazi, A.T. Esfanjani, J. Heshmati and A. Bahrami, 2011. The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extracts on Insulin Sensitivity and Some Inflammatory Indicators in Patients with Type 2 Diabetes: A Randomized Double-blind Control Trial. Pakistan Journal of Biological Sciences, 14: 775-779.

DOI: 10.3923/pjbs.2011.775.779

URL: https://scialert.net/abstract/?doi=pjbs.2011.775.779

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