Abstract: The effect of Nono on induced hypercholesterolemia in Albino rats was investigated. Induction was by feeding a high lipid cholesterol diet to the animals for two weeks. Following hypercholesterolemia, diet (HLCF) supplemented with Nono was administered to the rats for another eight weeks. The control group was fed normal diet only. The high density lipoprotein cholesterol (HDLC) value in rats fed with HLCF only or with supplement increased slightly above those recorded for the control. The values are significantly different at p≤0.05. The rat groups whose diets were supplemented with Nono had lower values for serum total cholesterol, triglyceride, low density lipoproteins and liver enzymes (Alanine and Aspartate aminotransferases) activity. These results demonstrate that increased consumption of Nono can be recommended for hypercholesterolemic individuals with a view to reducing the incidence of coronary heart diseases in Nigeria.