Abstract: Because of increased leisure time, the growing popularity of staying outdoors, it has become more and more imperative to study the molecular photobiological effects due to ultraviolet (UV) radiation on human skin. Information obtained from several studies is being used to constantly improve the quality of sunscreen preparations containing organic and inorganic filters. It also fostering the development of antioxidants and active agents that can be used in combination with or in addition to UV filters to provide better photoprotection for human skin. In this review, the examples are specified to illustrate the role and mechanism of highly specific and complex molecules obtained from natural sources; recognized as enzymes and examples are given to the development in skin care products: the use of topically applied DNA repair enzymes to prevent UVB radiation induced damage and the protective mechanism of superoxide dismutase and peroxidase to reduce UV-induced erythema, which can also be thought of as free radical scavenging ability.