Abstract: The aim of the present study was to determine the relationship of maternal serum levels of total homocysteine with adipocytokine leptin and oxidative stress assessed by levels of 8-Isoprostane and malondialdehyde in preeclampsia. The study population consisted of 30 preeclamptic patients and 30 matched healthy pregnant women. Serum levels of total homocysteine, 8-Isoprostane and total leptin were assessed using commercially available enzyme-linked immunosorbent assay methods. The amount of malondialdehyde was determined by the thiobarbituric acid assay. Statistical analysis was performed using the Mann-Whitney U test and Spearman’s correlation analysis. Serum levels of homocysteine, 8-Isoprostane, malondialdehyde and leptin were significantly increased in preeclamptic group compared with normal pregnant women. Levels of total homocysteine correlated positively with both 8-Isoprostane and malondialdehyde in preeclamptic group, while no association was found with adipocytokine leptin. The results of the present study showed that in preeclamptic women, maternal serum levels of total homocysteine were correlated with oxidative stress but not with leptin.