Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Medical Sciences
  Year: 2007 | Volume: 7 | Issue: 3 | Page No.: 402-407
DOI: 10.3923/jms.2007.402.407
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Vitamin B12 and Folate Deficiencies and Hyperhomocysteinemia in Elderly

Ali A. Alshatwi

Abstract:
The object of this study was to evaluate the levels of homocysteine (Hcy) and to evaluate the status of vitamin B12 and folate in elderly males living in the Riyadh city. Notably 34.1 and 88.6% of subjects had vitamin B12 and folate intakes below the DRI, respectively. Mean serum vitamin B12 was 298.8±114 pmol L-1 Moreover, low serum vitamin B12 was observed in 5.6% of sample subjects (<148 pmol L-1) and 23.3% had marginal vitamin B12 deficiency (148-221 pmol L-1). Mean serum folate was 8.6±2.3 ng mL-1. No one of the study subjects had a serum folate below 3 ng mL-1. However, 11.4% of subjects had marginal folate deficiency, with serum folate between 3-6 ng mL-1. Mean serum Hcy level was 12.3 ± 3.5 μmol L-1 and was inversely correlated with serum vitamin B12. Nearly, fifteen percent (14.8%) of elderly people had HHcy (Hcy>15 μmol L-1). Serum Hcy levels were increased significantly with age, in contrast serum vitamin B12 levels were decreased significantly with age. In conclusion, low serum levels of vitamin B12 and HHcy exist in older Saudi. Serum Hcy level in elderly Saudi is markedly increased with age and is attributable more to cobalamin deficiency than to folate deficiency. The vitamin B12 and folate status of elderly People (≥ 60 years) should be regularly controlled and a general supplementation with vitamin B12 and folate should be considered.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Curcumin and Tetrahydrocurcumin Restore the Impairment of Endothelium-dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings
  •    Diagnostic Value of Homocysteine and Other Preeclampsia Markers: Relationship with Severity
  •    Homocysteine and its Association with Lipid Peroxidation and Leptin in Preeclampsia
How to cite this article:

Ali A. Alshatwi , 2007. Vitamin B12 and Folate Deficiencies and Hyperhomocysteinemia in Elderly. Journal of Medical Sciences, 7: 402-407.

DOI: 10.3923/jms.2007.402.407

URL: https://scialert.net/abstract/?doi=jms.2007.402.407

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom