Abstract: In the present study, antihyperglycemic effect of oral administration of ethanolic extract of M. koenigii leaves (200 mg/kg/day) for 30 days on carbohydrate metabolizing enzymes in the liver and kidney of streptozotocin induced diabetic rats was evaluated. Glibenclamide was used as a standard reference drug. Significant increase in blood glucose and glycosylated hemoglobin and a concomitant decrease in the levels of insulin and liver glycogen were observed in diabetic rats. Increased activities of lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-diphosphatase and glycogen phosphorylase and decreased activities of hexokinase, pyruvate kinase and glycogen synthase were observed in diabetic rats. These alterations were restored to near normal in the liver and kidney after treatment with M. koenigii leaf extract indicating that the therapeutic role of M. koenigii leaves in moderate streptozotocin induced diabetes.