Abstract: Background and Objective: Innovation is important to building a competitive advantage for businesses. Furniture industry is another industry that focuses on innovation so that products are more modern and distinctive than their competitors. But in the innovation of the organization's products, there are many factors that affect the success. This research aimed to study factors that impact on the creation of innovation for entrepreneur in furniture industry business. Materials and Methods: The sample group includes 400 people who were in furniture industry business. The instrument was a questionnaire. Statistics used stepwise multiple regression. Results: The results showed that factors on general characteristics that impact on creating innovation contain (1) Business operation period less than 5 years, (2) The majority product of the business is the built-in type, (3) The public company limited type of business, (4) The listed companies in stock market and (5) The registered capital is between 10-50 million baht. The factors on internal management of the organization include (1) Business structure aspect, (2) Technology aspect, (3) Organizational culture/innovation aspect and (4) Interpersonal communication aspect. Conclusion: Creating innovative manufacturing enterprise, attention is needed to factors that are a general characteristics of the organization and the internal management of the organization. This will make the organization succeed in innovation.