Abstract: Background and Objective: Globally, men constantly seek medical help for problems associated with fertility. Male infertility has been linked with several factors, therefore, different of approaches are required to resolve this problem. This study evaluated the ameliorating effect of sesame seeds on caffeine-induced sperm toxicity in male albino rats. Materials and Methods: Twenty healthy male albino rats of 12 weeks old were used for this study. The 20 male rats were randomly divided into four groups of five rats each using a completely randomized design. The animals were acclimatized for 1 week before the commencement of the treatment. Group A served as control and received only water and pellet feed while Group B received 200 mg kg–1 b.wt. of caffeine only. Group C received 1 g kg–1 b.wt. of sesame (S. indicum) only and group D received 2 g kg–1 b.wt. of sesame and 200 mg kg–1 b.wt. of caffeine (C+S). The treatments lasted for a period of 65 days. Results: There was no significant difference in the weight of testes, sperm viability, semen pH and sperm motility in caffeine treated animals when compared with the control. Results showed statistically significant (p<0.05) reduction in weight of epididymis, epididymal sperm count and a concomitant increase in sperm head abnormalities in caffeine treated rats when compared with the control. However, sesame ameliorated the caffeine induced effect in weight of epididymis, sperm count and sperm head abnormalities in albino rat models. Conclusion: The results obtained from this study revealed that sesame seeds possess the potential to ameliorating toxicities on weight epididymis, sperm count and sperm head abnormalities induced by caffeine in albino rat as mammalian models.