Abstract: Bombax ceiba Linn. (Silk cotton tree) is a well known ethno-medicinal plant employed to treat a wide variety of disorders in man and animals. In the present study, its root powder was evaluated for its effect on serum lipids, plasma fibrinolytic activity and antioxidant potential in individuals with stable Ischemic Heart Disease (IHD). Fifty patients of IHD were selected and randomly divided in two groups of twenty five each. Group I (treated group) received 1.5 g root powder twice daily for 12 weeks, while group II (placebo group) received matched placebo for similar duration. Blood samples were collected in fasting state initially and at an interval of six weeks, till the end of the study. Administration of 3 g B. ceiba root powder significantly (p<0.01) increased plasma fibrinolytic activity by 69.44% and serum total antioxidant status (p<0.05) by 106% at the end of the study. Furthermore, a significant decrease was observed in total cholesterol (p<0.01), triglycerides (p<0.05), Very Low Density Lipoprotein Cholesterol (VLDL-C) (p<0.05), Low Density Lipoprotein Cholesterol (LDL-C) (p<0.001) levels and Atherogenic Index (AI) (p<0.05) along with a significant rise in High Density Lipoprotein Cholesterol (HDL-C)/Low density lipoprotein cholesterol ratio (p<0.05) after 12 weeks of B. ceiba administration. In the placebo group, there were no significant alterations in any of the parameters at the end of study. The drug was tolerated well without any significant side effects. This study has first time scientifically validated the effect of B. ceiba root on modification of multiple coronary risk parameters in man.