Abstract: Plants contain many important and potential therapeutic agents for treating several diseases of man. In this study, we investigated and compared the hypoglycemic abilities and antioxidant enzymes activities of aqueous extracts of horseradish (Moringa oleifera) leaf and nutmeg (Myristica fragrans) seed on Alloxan-induced diabetic albino rats with the aim of alleviating oxidative stress. Hyperglycemia was induced in rats using alloxan intra-peritoneally (ip). Two groups of fifteen wistar albino rats each were fed with water and rat pellets for one week to serve as control stage 1 (Non-diadetic rats). Five rats from each group were separately weighed and sacrificed. The remaining animals from each group were injected with 0.5 mL each of alloxan (35 mg kg-1 b.wt.) which was observed for another week with normal feeding, this served as stage 2 (Diabetic rats). Five animals from each group were also weighed and sacrificed. After the second stage, the remaining animals from each group were treated with 0.5 mL each of 30% aqueous extracts of Moringa oleifera leaf and Myristica fragrans seed, respectively for another week which served as stage 3 (Treated rats). The last sets of rats from each group were finally weighed and sacrificed. Blood samples were collected from each stage and group for fasting blood glucose determination in whole blood. While glutathione, glutathione peroxidase, superoxide dismutase, catalase and Malonaldehyde (MDA) were determined from plasma. The results of this study revealed that all the extracts caused hypoglycemea; increased weight, GSH, GPx, catalase and percentage inhibition of SOD but reduced Malonaldehyde (MDA) concentrations after treatments.